Highlights the study conducted by the researchers at the Cornell University Medical Center in New York regarding the effects of advanced transitional cell carcinoma (TCC) on patients treated with...
3 In their study, Togashi and colleagues aimed to evaluate if the dose reduction of apalutamide would affect skin-related AEs and CRPC-free survival in 107 patients with metastatic castration-sensitive prostate cancer (mCSPC; n = 72) or nonmetastatic castration-resistant p...
All red blood cell transfusions were assumed to contain the same number of cells and a unit of red blood cells is approximately 200 mL. The total red cell loss volume (TRCL) was calculated by multiplying PBV by the change of Hct or Hb and the total perioperative...
MDR chemosensitization. In the upper part of the figure the dose-response growth curves of drug sensitive parental cell lines (CCRF-CEM and HL60) and their derivative MDR variants (CEM-VBL100 and HL60/DNR) are shown (Panel A). The cells were cultured for 72 h in medium containing increa...
www.nature.com/scientificreports OPEN Carotid chemoreceptor denervation does not impair hypoxia- induced thermal downregulation Received: 15 November 2018 Accepted: 5 March 2019 Published: xx xx xxxx but vitiates recovery from a hypothermic and hypometabolic state in mice Sebastiaan D. Hemelrijk1...
We reasoned that the chemo/cytokines most likely to induce placental gene expression would have increased levels in maternal plasma and highly expressed cognate receptor(s) in decidua and placenta. Hence, we correlated changes in IL-6 and CCL20 plasma concentrations (Luminex log2FC, LPS vs. Ctrl...
Given that resistance to high-dose MEL has clearly been linked to DNA repair proficiency in myeloma cells, we tested the combination of PARPi and MEL and found a strong synergy in vitro and in vivo when tested in chemosensitive cells, providing a strong rationale for testing this combination ...
The model predicted a linear relationship between node connectivity and importance to in vivo fear consolidation which was tested in vivo with node-specific chemogenetic silencing in later behavioral experiments. The results found, unequivocally, that silencing of higher degree nodes, such as the CA1...
(via NO/adenosine/COX), and stimulate the release of exosomes carrying chemo-active compounds to target tissue [38,85,95]. Exosomes can also carry pro-inflammatory compounds and chemokines in addition to cardioprotective substances, and are, therefore, ‘a double-edged sword’ in inflammation [...
chest pain associated with angina is due to stimulation of both chemosensitive and mechanore- ceptive receptors of unmyelinated nerve cells found within cardiac muscle fibers and around the coronary vessels. This stimulation cascade is thought to occur when lactate, sero- tonin, bradykinin, histamine...