2023年1月5日,英国剑桥大学Tom L. Blundell与Shikang Liang(梁世康)在Nature Structural & Molecular Biology上发表了文章Human DNA-dependent protein kinase activation mechanism,揭示了人类DNA依赖性蛋白激酶(DNA-PK)激活的分子机理。 ...
其中,DNA-PK是非同源末端连接(Non-homologous end joining,NHEJ)通路中的关键蛋白激酶,由DNA-PKcs(DNA-PK催化亚基)、Ku70/80和DNA末端组成,其全酶装配会进一步招募NHEJ相关的连接酶和修复蛋白,包括DNA连接酶IV、XRCC4(X-ray cross...
which inhibit its chaperone function for AMP-activated protein kinase (AMPK). This leads to the mitochondrial and matabolic decline as AMPK is critical for mitochondrial biogenesis and energy metabolism. DNA-PK is also highly associated with Alzheimer's disease (AD). In AD brains, the level of...
A phosphatidyl inositol kinase family (PI[3]K) protein has a role in transcription, replication, immunoglobulin gene switching, cancer and DNA repair. In cells deficient in DNA-PK non-homologous end-joining is preferred whereas homologous recombination is reduced (Convery E et al 2005 Proc Natl ...
[1]Up‐regulation of DNA‐dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma[J].SatoruShintani;MarikoMihara;ChunnanLi;YuujiNakahara;SatoshiHino;Koh‐ichiNakashiro;HiroyukiHamakawa.Cancer Science,2005(10)
DNA-PK (DNA-dependent protein kinase, 8q11)doi:10.1007/978-1-4020-6754-9_4741A phosphatidyl inositol kinase family (PI[3]K) protein has a role in transcription, replication, immunoglobulin gene switching, cancer and DNA repair. In cells deficient in DNA-PK non-homologous......
DNA-dependent protein kinase (DNA-PK) is a key component in the repair of DNA double-strand breaks via non-homologous end-joining. Studies have found elevated DNA-PK expression and activity in hepatocellular carcinoma (HCC) to be strongly correlated with increased tumor grade, resistance to DNA...
Frederick W. Goldberg. The Discovery of7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one(AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK)Inhibitor, J. Med. Chem, 2020. (DOI:10.1021...
非同源末端修复(Non-homologous end joining,NHEJ)是哺乳动物体内最主要的DNA双链断裂修复机制,主要由DNA-PK(DNA-dependent protein complex)复合体来介导。早期的研究显示,NHEJ主要表现为一个线性的过程:Ku70/80首先识别DNA末端,然后招募DN...