2023年1月5日,英国剑桥大学Tom L. Blundell与Shikang Liang(梁世康)在Nature Structural & Molecular Biology上发表了文章Human DNA-dependent protein kinase activation mechanism,揭示了人类DNA依赖性蛋白激酶(DNA-PK)激活的分子机理。...
DNA-PK(DNA-dependent protein kinase)是一种蛋白质,是DNA双链断裂修复(Double-strand break repair, DSBR)最主要途径——非同源末端连接(Non-homologous end joining, NHEJ)中的一个关键组分,由一个催化亚单位(DNA-PKcs)和两个结合DNA的亚单位(Ku70和Ku80)组成的复合物。DNA-PK 在DNA修复中起着枢纽和组织者...
在2023 年这篇论文中,梁世康揭示了 DNA 依赖性蛋白激酶(DNA-Dependent Protein Kinase, DNA-PK)激活的详细分子机制,并在激活催化过程中发现了重要的蛋白质结构域。 结合之前的研究 [1],让他得以详细了解从 DNA 依赖性蛋白激酶催化亚基、到 DNA 依赖性蛋白激酶全酶复合物的激活分子机理,为人类 DNA 损伤修复和 ...
非同源末端修复(Non-homologous end joining,NHEJ)是哺乳动物体内最主要的DNA双链断裂修复机制,主要由DNA-PK(DNA-dependent protein complex)复合体来介导。早期的研究显示,NHEJ主要表现为一个线性的过程:Ku70/80首先识别DNA末端,然后招募DN...
DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460) Homo sapiens (Human). 參數根據以下信息計算得出 FT CHAIN 1-4128 DNA-dependent protein kinase catalytic 分子量 (Da) 469088.83 ...
DNA-PK抗体是针对DNA依赖性蛋白激酶(DNA-PK)这一特定蛋白质的特异性抗体。DNA-PK是一种在DNA双链断裂(DSB)修复过程中起关键作用的核蛋白复合体。
A phosphatidyl inositol kinase family (PI[3]K) protein has a role in transcription, replication, immunoglobulin gene switching, cancer and DNA repair. In cells deficient in DNA-PK non-homologous end-joining is preferred whereas homologous recombination is reduced (Convery E et al 2005 Proc Natl ...
DNA-PK overview DNA-dependent protein kinase (DNA-PK) The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase which is activated after the interaction with its target DNA. DNA–PK is a complex composed of a large catalytic subunit named DNA–PKcs and a heterod...
Frederick W. Goldberg. The Discovery of7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one(AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK)Inhibitor, J. Med. Chem, 2020. (DOI:10.1021...
2020年3月9日讯/生物谷BIOON/---DNA依赖性蛋白激酶(DNA-dependent protein kinase, DNA-PK)是结合DNA并修复双链断裂的最重要的酶之一。这种修复方式对于产生能够帮助免疫系统抵御入侵者的受体至关重要。但是DNA-PK不仅结合DNA,而且还结合RNA。尽管科学家们早在几十年前就知道了这一点,但他们还不完全了解哺乳 ...