DNA-dependent protein kinase (DNA-PK) is a high-molecular-weight kinase that binds to and is activated by free double-stranded DNA ends. The primary function of DNA-PK is to promote DNA end synapsis and regulate DNA end processing in the nonhomologous end-joining pathway of double-strand ...
Additional Information How to Cite Dynan, W. S. and Hardin, J. A. 2002. DNA-Dependent Protein Kinase (DNA-PK). Encyclopedia Of Molecular Medicine. Author Information Institute for Molecular Medicine and Genetics, Augusta, Georgia Publication History Published Online: 15 JAN 2002 ...
3., 4., 5. DNA-dependent protein kinase (DNA-PK) is a key node within the DDR, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining (NHEJ),6 a common repair process for DSBs which are the most cytotoxic form of DNA damage...
Purity:≥98% ViewAll Products for DNA-dependent Protein Kinase Inhibitors Product Details Reviews Biological ActivityTechnical DataProduct DatasheetsCalculators Biological Activity AZD 7648 is a potent (IC50= 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over...
The DNA-dependent protein kinase (DNA-PK) is a key driver of one of the main pathways for repair of DNA double-strand breaks (DSB) via the non-homologous end-joining mechanism12,13,14. Inhibitors of its catalytic activity have been shown to potentiate the antitumor activity of DNA DSB-ind...
The DNA-dependent protein kinase (DNA-PK) plays an important role in mammalian DNA double-strand break repair and immunoglobulin gene rearrangement. The DNA-PK holoenzyme is activated by assembly at DNA ends and is comprised of DNA-PKcs, a 460 kDa protein kinase catalytic subunit, and Ku, a...
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Presents research which showed that the protein p53 response is functional in mouse embryonic fibroblasts lacking DNA-dependent protein kinase (DNA-PK). Activation of p53 by damage to DNA in cells; Effects of irradiation-induced DNA damage; Traits of the DNA-PK-deficient cell line SCGR11; DNA-...
The DNA-dependent protein kinase (DNA-PK), consisting of Ku and the DNA-PK catalytic subunit (DNA-PKcs), and the DNA ligase IV-XRCC4 complex function together in the repair of DNA double-strand breaks by non-homologous end joining. These protein complexes are also required for the ...
DNA-dependent protein kinase (DNA-PK) becomes activated in response to DNA double strand breaks, initiating repair by the non-homologous end joining pathway. DNA·PK complexes with the regulatory subunit SAPSR1 (R1) of protein phosphatase-6 (PP6). Knockdown of either R1 or PP6c prevents DNA...