1. 结合区域 ...or),转录因子均具备与DNA 相结合之能力,此等结合区域(DNA-binding domains)之基本构型有那四种?xuelele.com.tw|基于2个网页 例句 释义: 全部,结合区域 更多例句筛选 1. The DNA binding domains and natural nuclear localization signal sequences make his tones excellent candidates for effec...
Definition The recognition and binding of specific DNA sequences is achieved by protein domains structured as basic domains next to helix‐loop‐helix or leucine zipper structures, or as zinc finger, helix‐turn‐helix, or less well defined motifs. Transcription Factors and Regulation of Gene Expres...
1.4 DNA-binding Domains DNA-binding domains adopt different structures, and the interaction of these domains with DNA can be established through alpha helices, beta sheets, or disordered regions (Figure 1.3; Pabo and Sauer, 1992). Usually, the DNA-binding domain forms a module that can be sepa...
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a ...
OmpR belongs to a subfamily of at least 50 response regulators with homologous C-terminal DNA-binding domains of approximately 98 amino acids. Sequence homology with DNA-binding proteins of known structure cannot be detected, and the lack of structural information has prevented understanding of many ...
Speltz, T.E., Qiao, Z., Swenson, C.S.et al.Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.Nat Biotechnol41, 541–551 (2023). https://doi.org/10.1038/s41587-022-01504-x Download citation ...
Thus, protein domains that bind DNA provide suitable structures for presenting signals to the nuclear transport machinery. Nuclear transport receptor binding to a DBD-containing protein should, in addition, block the interaction of the protein with DNA. In the case of GR and probably other nuclear...
Investigation of long-range intra- and interdomain communications in the p53 tetramer–DNA complex was performed by means of an atomistic model that included the tetramerization helices in the C-terminal domain, the DNA-binding domains and a consensus DNA-binding site of 18 base pairs. ...
Summary: Based on the manual annotation of transcription factors stored in the TRANSFAC database, we developed a library of hidden Markov models (HMM) to represent their DNA-binding domains and used it for a comprehensive classification. The models constructed were applied on the UniProt/Swiss-Prot...
Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1: Mechanism for an increase in DNA-... Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1: Mechanism ...