DNA Repair Mechanisms Despite the remarkable accuracy of DNA replication, errors can occur. Additionally, DNA can be damaged by various factors, such as exposure to radiation or chemicals. To maintain the integrity of genetic information, cells have evolved several DNA repair mechanisms. One of the...
The inactivation may be due, for example, to point mutation, deletion, gene conversion, epigenetic silencing or other mechanisms [72]. The protein encoded by the gene will either not be expressed or be expressed in a mutated form. Consequently the DNA repair or DNA damage response function ...
Drug resistance in gynecologic cancers: Findings and underlying mechanisms DNA repair mechanisms Mismatch repair (MMR) MMRhelps in recognizing a mismatchedDNA base, and then repairing, followed by re-assembling the DNA in a precise manner[29]. Exposure to chemotherapy disables the MMR process, leadin...
DNA repair mechanisms DNA damage response is a natural process by which cells maintain genome integrity and prevent harmful mutations [142, 143]. Platinum-based drugs can act by inducing direct or indirect DNA damage, causing inhibition during the progression of cell-cycle progression. This causes ...
Helicase-dependent DNA damage response and repair mechanisms help cells to cope with endogenous or exogenous stress to prevent chromosomal instability and maintain cellular homeostasis. Inactivating mutations in DNA helicase genes are linked to genetic disorders that are frequently associated with various can...
The two major mechanisms of DSB repair in mammalian cells are non-homologous end joining (NHEJ) and homologous recombination. In this Review, we consider DSB repair-pathway choice in somatic mammalian cells as a series of ‘decision trees’, and explore how defective pathway choice can lead to...
All these methods are collectively termed as DNA REPAIR mechanisms. Similar to DNA replication, transcription and translation, the process of DNA repair is also a prime molecular event in the cells which is very essential for the ultimate survival of the cells and also for the survival of the ...
In non-neoplastic cells, accurate DNA repair is essential to prevent genetic instability, a driving force in tumorigenesis. Thus, cancer cells often display genetic or epigenetic alterations that affect DNA repair factors [12]. Paradoxically, DNA repair mechanisms are also paramount to the removal ...
In: DNA Repair Mechanisms. Edited by P. C. HANAWAEL.TC,. FRIEDBEanRdGC. F. Fox. Academic Press, New York.HAYNESR,. H., L. PRAKASHM,.A. RESNICK,B. S. Cox, E. Mous- TACCHI andJ. B. BOYD1, 978 DNA repair in lower eucaryotes. In: DNA Repair Mechanisms, Edited by P. C. ...
Improved nonviral gene editing would be a powerful approach to unraveling DNA repair mechanisms, a useful laboratory technique and a promising strategy for the treatment of a multitude of diseases3. One high-efficiency nonviral gene editing strategy codelivers ribonucleoprotein (RNP) formulations ...