DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. Depending on the type of damage inflicted on the DNA molecule, a variety of repair mechanisms are adopted to restore the lost information, including direct rev...
Then, we discuss how interactions among these different repair processes can lead to different base editing outcomes. Through this review, we hope to promote thoughtful discussions on the DNA repair mechanisms of base editing, as well as help researchers in the improvement of the current base ...
Mechanisms of nuclear trafficking mediated by NLS A schematic model for nuclear protein import through NPC illustrates how can a complex biological function can be generated by a spatially and temporally organized cycle of interactions between cargoes, carriers and Ran GTPase [46]. NLS-dependent protei...
Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest p pBackground/p pUV-induced damage can induce apoptosis or trigger DNA repair mechanisms. Minor DNA damage is thought to halt the cell cycle to allow effec... HL Lo,S...
Brain vascular scRNA-seq data provide insight into brain disease mechanisms. Three types of disease mechanisms are illustrated. For genes implicated in the transport of Alzheimer’s amyloid-β (Aβ) peptide across the BBB, it is noteworthy that several different cell types of the neurovascular unit...
Such differences in mutation may be due to variation in exposure to carcinogens and/or to differences in the expression of DNA repair proteins between tissues and/or tumor types. Differences in mutational biases between tumor types and as a function of smoking carcinogen exposure have been well ...
RNA, complex compound of high molecular weight that functions in cellular protein synthesis and replaces DNA as a carrier of genetic codes in some viruses. RNA consists of ribose nucleotides and the nitrogenous bases adenine, guanine, cytosine, and uraci
In both UC and CRC patients, the absence of SLC16A1 disrupts the transport of bacterial products via H+-coupled short-chain fatty acid transport mechanisms (Sivaprakasam et al. 2017). Furthermore, our observations indicate a notable suppression in the levels of SLC16A1 in both UC patients an...
Ciliated cells elevated the expression of interferon-stimulated genes (Fig.3e, fand Supplementary Data5), which are involved in viral response mechanisms and are crucial in driving and maintaining lung inflammation, for example, by promoting antigen presentation or stimulating cytokine production43. Cili...
In vitro/in vivo assessment and mechanisms of toxicity of bioceramic materials and its wear particulates. RSC Advances, 4(25): 12763–12781. https://doi.org/10.1039/C3RA44483J Article Google Scholar Vakil MK, Mansoori Y, Al-Awsi GRL, et al., 2022. Individual genetic variability mainly...