Feng Xu et al,ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity, Cell Death & Differentiation (2025). DOI: 10.1038/s41418-025-01472-0. DNA repair mechanism may hold key to overcoming tumor ...
图1. DSBs 修复途径 Alternative pathways of DNA double-strand break repair. Homologous recombination is the preferred route in yeast. It involves invasion of the broken DNA strands into a homologous DNA duplex molecule. This process requires Rad52 (a DNA end-binding protein), Rad51 (which forms...
Fragile DNA Repair Mechanism Reduces Ageing in Multicellular Model Kristian Moss Bendtsen*, Jeppe Juul, Ala Trusina. DNA damages, as well as mutations, increase with age. It is believed that these result from increased genotoxic stress and decreased capacity for DNA repair. The two causes are ...
16.Singer B, Hang B. 1997. What Structural Features Determine Repair Enzyme Specificity and Mechanism in Chemically Modified DNA??. Chem. Res. Toxicol.. 10(7):713-732.17.Lindahl T. 1999. Quality Control by DNA Repair. 286(5446):1897-1905.18.Caldecott KW, Aoufouchi S, Johnson P, Shall...
讲座标题:Breaking new ground: direct observation reveals elusive DNA repair mechanism 直播时间:2024年9月26日,晚上11:00(北京时间) 温馨提示:直播时间较晚,注册后您也将在直播后获得录播链接 参与方式:请点击文章链接注册报名(Nature网络...
^Buschta-Hedayat N, et al. Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6090-5. ^Sugasawa K, et al. A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes Dev. 20...
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DNA Repair and Nobel Prize in Chemistry (2015) The Royal Swedish Academy of Sciences awarded the 2015 Nobel Prize in Chemistry for the discovery and contributions of DNA repair mechanism. The Nobel Prize in Chemistry this year was shared by three scientists namely Thomas Lindhal, Paul Modrich an...
3. Yuzenkova, Y. et al. Stepwise mechanism for transcription fidelity. BMC Biol. 8, 54 (2010). 4. Epshtein, V. et al. UvrD facilitates DNA repair by pulling RNA polymerase backwards. Nature 505, 372–377 (2014) . 5. Park, J. S., Marr, M. T. & Roberts, J. W. E. coli ...
(yellow and orange boxes) by a less well-studied mechanism. It also requires Rad52, and extensive degradation of the two unannealed strands results in considerable loss of genetic material. Nonhomologous end joining rejoins the two broken ends directly. It requires the DNA end-binding protein ...