The DNA methylation field has matured from a phase of discovery and genomic characterization to one seeking deeper functional understanding of how this modification contributes to development, ageing and disease. In particular, the past decade has seen many exciting mechanistic discoveries that have subst...
DNA methylation in mammals. Cold Spring Harb. Perspect. Biol. 6, a019133 (2014).2、Baylin, Stephen B., and Peter A. Jones. "Epigenetic determinants of cancer." Cold Spring Harbor perspectives in biology 8.9 (2016): a019505.3、Xu C, Corces VG. Nascent DNA methylome mapping reveals ...
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“Determination of DNA adenine methylation in genomes of mammals and plants by liquid chromatography/mass spectrometry,”RSC Adv., vol. 5, no. 79, pp. 64046–64054, Jul. 2015, doi: 10.1039/c5ra05307b.
DNA methylationEpigenomicsHigh-throughput sequencingOmicsA complete understanding of the dynamics and function of cytosine modifications in mammalian biology is lacking. Central to achieving this understanding is the availability of techniques that permit sensitive and specific genome-wide mapping of DNA ...
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Special functions of DNA methylation include the marking of one of the parental alleles of many imprinted genes, a group of genes essential for growth and development in mammals with a unique parent-of-origin expression pattern, a role in stabilizing X-chromosome inactivation, and centromere ...
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DNA Methylation and Demethylation in Mammals Cell type-specific DNA methylation patterns are established during mammalian development and maintained in adult somatic cells. Understanding how these pat... ZX Chen,AD Riggs - 《Journal of Biological Chemistry》 被引量: 601发表: 2011年 DNA methylation an...