2) Goodnow Jr, Robert A., Christoph E. Dumelin, and Anthony D. Keefe. "DNA-encoded chemistry: enabling the deeper sampling of chemical space."Nature Reviews Drug Discovery16.2 (2017): 131. 3) Clark, Matthew A., et al. "Design, synthesis and selection of DNA-encoded small-molecule li...
近日,美国斯克里普斯研究所Matthew D.Disney教授在《J. Am. Chem. Soc.》上发表了题为“DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC)”的文章。核糖核酸酶靶向嵌合体(核糖TACs)通过促进RNA和核糖核酸酶(RNase)之间的相互作用来诱导RNA靶标的降解。文章描述了DNA编码...
Hitgen focuses on the development of new drugs and is committed to creating the world's best quality DNA Encoded Library with independent intellectual property rights as a "new engine" for the creation of new drugs.
Instead of looking for DNA/DNA hybrids to identify the gene of interest from a library, the protein itself can be identified byimmunological screening. This method relies on the production of the protein encoded by the gene of interest and therefore assumes that the cloned gene is efficiently ex...
USA. HitGen has established leading technology platforms to enable the discovery and optimization of small molecules and nucleic acid drugs. Our key technology platforms include world-leading DNA-encoded library technology (DEL), fragment-based drug discovery and structure-based drug design technologies ...
The effects of design parameters on the coverage of the chemical space by a DNA-encoded library and on the properties of encoded compounds are discussed.Zhang, YingX-Chem, Inc.Franzini, Raphael M.University of Utah
DNA编码分子库(DNA-encoded chemical libraries)作为一项新型的药物研发手段,将化学合成与基因编码策略有机地结合起来,能高效构建大超大规模分子库(1012个化合物),进行针对疾病相关靶标的高通量筛选。[1] 最近几年,随着DNA兼容化学反应的不断进步,这类被称为“扫条码,找新药”的技术发展迅速,被多家制药公司用于新药...
DNA-Encoded Library (DEL) screening is designed to maximize your chance for success while searching for unique binders to your biological targets in vast (>11 billion compounds) chemical space. Hit finding is focused on mode of action (MoA) and delivered with ...
This raises the question of compound library design. Keywords: bioactive small molecule; DNA-encoded chemistry; DNA-encoded library; drug identification; molecular evolution; screening Introduction Biomedical research nowadays benefits a lot from rapid progress in ‘omics’-technologies (Rigden et al., ...
DNA-encoded library (DEL) technology is a novel ligand identification strategy that allows the synthesis and screening of unprecedented chemical diversity more efficiently than conventional methods. However, no reports have been published to systematically study how to increase the diversity and improve th...