6.Conole, Daniel; HHunter, James; J Waring, Michael. The maturation of DNA encoded libraries:opportunities for new users. Future Medicinal Chemistry (2021), 13(2), 173-191. 7.Flood,Dillon T.; Kingston, Cian; Vantourout, Julien C.; Dawson, Philip E.; Baran,Phil S. DNA Encoded Libra...
DNA编码化合物库(DNA-encoded libraries,DELs)是一个与特定DNA序列共价连接的小分子化合物库,能够用于针对生物靶标进行高效筛选。通过对结合化合物的DNA序列进行扩增和测序,可以有效地识别该化合物。 正如DEL技术的创始人Sydney Brenner和Richard Lerner所说:“通过将遗传学和有机合成化学的多功能性相结合,我们已经将分...
Gitte;Vestergaard, Mikkel; Jin, Lei; Zhao, Shuai; Wingler, Laura M.; Rambarat, PaulaK.; et al. Small-Molecule Positive Allosteric Modulators of the β2-AdrenoceptorIsolated from DNA-Encoded Libraries. Molecular Pharmacology (2018)...
2.Madsen,Daniel; Azevedo, Carlos; Micco, Iolanda; Petersen, Lars Kolster; Hansen, NilsJakob Vest. An overview of DNA-encoded libraries: A versatile tool for drugdiscovery. Progress in medicinal chemistry (2020), 59, 181-249. 3.Satz, Alexander L.;Kollmann, Christopher S.; Paegel, Brian M...
DNA-encoded library (DEL) has come of age and become a major technology platform for ligand discovery in both academia and the pharmaceutical industry. Technological maturation in the past two decades and the recent explosive developments of DEL-compatible chemistries have greatly improved the chemical...
DNA-encoded library (DEL) technology is a novel ligand identification strategy that allows the synthesis and screening of unprecedented chemical diversity more efficiently than conventional methods. However, no reports have been published to systematically study how to increase the diversity and improve th...
DNA-encoded compound libraries are a highly attractive technology for the discovery of small molecule protein ligands. These compound collections consist of small molecules covalently connected to individual DNA sequences carrying readable information ab
chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries. ...
The ForenSeq DNA Signature Prep Kit is part of a complete, fully validated DNA-to-data solution designed for forensic genomics applications. It includes all reagents to prepare next-generation sequencing (NGS) libraries from forensic DNA samples. ...
Mimicking traditional digital neural networks with DNA-encoded ‘enzymatic’ neurons overcomes issues with other chemical approaches, and could allow notable increases in miniaturization and molecular implementation of these AI models, with potential applications including DNA data storage or cancer diagnosis....