Gitte;Vestergaard, Mikkel; Jin, Lei; Zhao, Shuai; Wingler, Laura M.; Rambarat, PaulaK.; et al. Small-Molecule Positive Allosteric Modulators of the β2-AdrenoceptorIsolated from DNA-Encoded Libraries. Molecular Pharmacology (2018)...
DNA编码化合物库(DNA-encoded libraries,DELs)是一个与特定DNA序列共价连接的小分子化合物库,能够用于针对生物靶标进行高效筛选。通过对结合化合物的DNA序列进行扩增和测序,可以有效地识别该化合物。 正如DEL技术的创始人Sydney Brenner和Richard Lerner所说:“通过将遗传学和有机合成化学的多功能性相结合,我们已经将分...
这些话源自于两位老科学家在2017年的Angew. Chemie期刊的专栏文章《DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs》[8],文中这样说到: 1.NIH(美国国立卫生研究院)每年花费300亿美金用于寻找治疗疾病的化学分子; 2.生物学家最大的问题是没有获得规模庞大的化合物库,高通量筛选...
6.Conole, Daniel; HHunter, James; J Waring, Michael. The maturation of DNA encoded libraries:opportunities for new users. Future Medicinal Chemistry (2021), 13(2), 173-191. 7.Flood,Dillon T.; Kingston, Cian; Vantourout, Julien C.; Dawson, Philip E.; Baran,Phil S. DNA Encoded Libra...
最后,以DELT的发明人Richard A. Lerner 和Sydney Brenner几句意味深长的话作为本篇长文的结尾。这些话源自于两位老科学家在2017年的Angew. Chemie期刊的专栏文章《DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs》[8],文中这样说到: ...
Hitgen focuses on the development of new drugs and is committed to creating the world's best quality DNA Encoded Library with independent intellectual property rights as a "new engine" for the creation of new drugs.
EncodedLibrariesHTSChemistryBiologyDrug discoveryBindingIn 1992, Brenner and Lerner hypothesized that individual chemical transformations could be encoded in DNA, allowing the rapid synthesis and screening of large collections of small molecules. Since their report, huge investments into the development of ...
DNA-encoded library (DEL) technology is a novel ligand identification strategy that allows the synthesis and screening of unprecedented chemical diversity more efficiently than conventional methods. However, no reports have been published to systematically study how to increase the diversity and improve th...
3.Satz, Alexander L.;Kollmann, Christopher S.; Paegel, Brian M. DNA-encoded libraries in thepharmaceutical industry. Medicinal Chemistry Reviews (2020), 55, 547-564. 4.Goodnow, R. A. Jr. (ed.)A Handbook for DNA-Encoded Chemistry: Theory andApplications for Exploring Chemical Space and ...
technology platforms include world-leading DNA-encoded library technology (DEL), fragment-based drug discovery and structure-based drug design technologies (FBDD/SBDD), as well as the emerging technology platforms for synthetic therapeutic oligonucleotide technology (STO), and targeted protein degradation ...