The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogenesis of heart failure remain elusive. Here we show the critical role of DNA single...
control,DNAdamageresponsesandtumorigenesis[19–23,25–27]. Inthisstudy,weshowedthatNMIregulatesEMTviatheNF- κBpathway.WeobservedthatNMIexpressionismarkedlyreduced ininvasivegastriccancercellsandgastriccancertissues.Wedem- onstratedthatNMIoverexpressionreducedtheinvasionand migrationofgastriccancercells.Wefoundthat...
control,DNAdamageresponsesandtumorigenesis[19–23,25–27]. Inthisstudy,weshowedthatNMIregulatesEMTviatheNF- κBpathway.WeobservedthatNMIexpressionismarkedlyreduced ininvasivegastriccancercellsandgastriccancertissues.Wedem- onstratedthatNMIoverexpressionreducedtheinvasionand migrationofgastriccancercells.Wefoundthat...
suggest that a reduced sensitivity to cisplatin in differentiated TGCT components could result from a reduced expression of MMR proteins, in particular MSH2 and MLH1, which are involved in the recognition of cisplatin adducts and in activation of the DNA damage response pathway to initiate apoptosis...
Enhanced response to cisplatin after VIRMA knockdown was related to significant increase in DNA damage (with higher 纬H2AX and GADD45B levels) and downregulation of XLF and MRE11.#VIRMA has an oncogenic role in GCTs confirming our previous tissue-based study and is further involved in response ...
Cisplatin induced γH2AX (phosphorylated S139 H2AX histone), a hallmark of DNA damage; however, cisplatin failed to induce nuclear soluble cGAS (Fig. 3c). To exclude the effects of cell viability on cGAS subcellular localization, we performed MTT assays in cells treated with cisplatin or HSV-...
jackson,s.p.adj.bartek,thedna-damageresponseinhumanbiologyanddisease.nature,2009.461(7267):p.1071-8-ciccia,a.ands.j.elledge,thednadamageresponse:makingitsafetoplaywithknives.molcell,2010.40(2):p.179-204. aparicio,t.,r.baer,andj.gautier,dnadouble-strandbreakrepairpathwaychoiceandcancer.dnarepair(...
For many years, endogenous DSBs were studied by artificially inducing them, either by ionizing radiation; by using the rare-cutting endonuclease, I-SceI; or, more recently, by using the programmable nucleases Cas9 and Cas12a to study different aspects of the DNA damage response [23,24,25]. ...
In particular, the intracellular increase in ROS leads to an increase in mitochondrial biogenesis as an adaptive response that can be detected by measuring the mt/N ratio. The persistence of oxidative stress can cause damage to mitochondrial membranes, proteins, and DNA over time, causing ...
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as