The structure of DNA double helix The structure of DNA double helix DNA Directionality DNA backbone is formed by phosphodiester bond between the 5’ phosphate- and 3’ hydroxyl-groups of adjacent nucleotides; DNA double helix is stabilized by hydrogen bonds between the bases, and is antiparallel. ...
DNA fine structure and dynamics in crystals and in solution: the impact of BI/BII backbone conformations. Sugar–phosphate backbone conformations are an important structural element for a complete understanding of specific recognition in nucleic acid–protein i... D Djuranovic,B Hartmann - 《...
This quantification of the populations of BI and BII is of general interest because these sequence-dependent backbone states act on DNA overall structure, a key feature for DNA-protein-specific recognition. 展开 关键词: P-31 NMR-SPECTRA NF-KAPPA-B NUCLEIC-ACIDS COUPLING-CONSTANTS MOLECULAR ...
families, benchmark structure–energy quantum chemical calculations, parameterization of the dihedral space of simulation force fields, incorporation of arsenate into DNA, sugar–phosphate backbone self-cleavage in small RNA enzymes, and intricate geometries of the backbone in recurrent RNA building blocks...
In B-DNA, correlated transitions in the backbone ɛ(C4′-C3′-O3′-P) and ζ(C3′-O3′-P-O5′) occur. The transitions in ɛ and ζ occur from the more frequent t, g- to g-, t conformation, and the two structures are often referred to as BI and BII conformational substates,...
molecular biophysicsphysiological models/ backbone structureDNAbiological polaritydynamic structures/ A8715B Biomolecular structure, configuration, conformation, and active sitesA model for the biological polarity of DNA is presented and speculations about dynamic structures in biological systems are exposed....
Scaffolding residues M164 and Y165 locate in the center of the minor groove and widen the distance between two DNA backbones (Fig. 2c). Fig. 2: Mechanism of DNA base damage recognition by AAG in the nucleosome. a–c AAG identifies the damaged base by inserting the β3–β4 hairpin ...
phosphate backbone suggesting that these mutations cause disease by directly impairing DNA recognition (Fig.4d). Finally, six hTREX1 mutations (D18N/H, H195Y/Q, D200H/N) occur in residues that form the enzymatic DEDDh active-site motif and are known to be essential for divalent metal ion...
The three-dimensional structure of the triplex accommodates the 7G with less distortion of the phosphodiester backbone than would be required for an N9-glycosylated guanine in the same sequence position, but some changes in the positions of the phosphodiester backbone are present compared to a C+ ...
(positive for −SC and negative for +SC) produces different types of inter-segmental interactions along the plectonemes: +SC induces right-handed crossovers characterized by a strong groove-backbone interaction (i.e. the major groove of one helix interlocks with the minor groove of the other)...