DNADifference in the genomic compositions of prokaryotes is the basis of the diversity in their biological characters. However, besides their flora-or strain-specific genes,those floras with closer relationship in the evolution also have conserved “backbone sequences”, which reveal the marks of ...
on the dna backbone and stabilize duplex formation, while ammonium ion (nh 4 + ) can interact with hydrogen bonds between the bases (n) and destabilize duplex formation. since mg 2+ has a stabilizing effect similar to k + , ...
In general, histones are thought of as sequence-independent DNA binding proteins, and the crystal structure of the eucaryal nucleosome confirmed that most interactions are made between histone fold residues and the non-informational sugar-phosphate backbone of the DNA molecule 〚18〛. However, euc...
Moreover, the functions of POLB are intimately associated with the p53/PI3K/Akt signaling pathway, as p53 can stabilize the interaction between POLB and DNA backbone, while PI3K/Akt induces the expression of APE1, a significant enzyme in the BER pathway [114,115]. PREP is a peptidase able ...
By analyzing about 3700 backbones of folded proteins, the authors argued that something like Chargaff s rules exist in protein folding similarly as in the organization of DNA structures. The above conclusion was made by counting the numbers of contacts between two specific residues at a variable ...
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Furthermore, DNA circuitry is bio-compatible, thus well-suited for intra-cell operation. Using DNA to carry out Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for ...
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Figure 8. Effects of buffer ions on DNA duplex formation. Potassium and magnesium ions (K+ and Mg2+) bind to the phosphate groups (P–) on the DNA backbone and stabilize duplex formation, while ammonium ion (NH4+) can intera...
Sphingolipids are the second major component of lipids in the cell membrane, a subclass of amphipathic lipids that all include a sphingoid base backbone that is N-acylated with different fatty acid chains. This group consists of lipids such ceramide, sphingosin-1-phosphate (S1P), ceramide-1-ph...