临床前研究显示，在小鼠肿瘤模型上，ZG006具有显著的肿瘤抑制作用，使小鼠肿瘤完全消退。在非人灵长类动物中，ZG006显示出毒副作用低等良好的安全性特征。目前，ZG006正在进行一项1/2期临床试验，针对的适应症为SCLC。
- -If you want to create a new branch to retain commits you create, you may -do so (now or later) by using -c with the switch command. Example: - - git switch -c <new-branch-name> - -Or undo this operation with: - - git switch - - -Turn off this advice by setting config...
First, we ensured an adequate assay performance of the DLL3 IHC assay, by testing cell lines with known DLL3 expression as previously described in studies evaluating high grade neuroendocrine lung tumors and cell lines35. We tested 4 FFPE cell pellets from lung cancer cell lines with different ...
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Notch is a pleiotropic signaling family that has been implicated in pathogenesis of allergic airway diseases; however, the distinct function of individual Notch ligands remains elusive. We investigated whether Notch ligands, Jagged1 and DLL4, exert diffe
The toxicities included grade 3/4 cytokine release syndrome (CRS) occuring in 2 patients, as well as grade 3 confusional state, grade 2 infusion-related reaction, and a grade 3 nervous system disorder occuring in 1 patient each. In an interview with OncLive®, Wermke,...
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. Sci Transl Med. 2015;7:302ra136. Article PubMed PubMed Central Google Scholar Tanaka K, Isse K, Fujihira T, Takenoyama M, Saunders L, Bheddah S, et al. Prevalence of ...
≥ Grade 2 ICANS, respectively. The median time to onset of ICANS from the first dose of IMDELLTRATMwas 29.5 days (range: 1 to 154 days). ICANS can occur several weeks following administration of IMDELLTRATM. The median ti...
Grade High-end Toys Customized Customized Transport Package Cardboard Box Specification 251*81*36mm Origin Guangdong/Huizhou Production Capacity 300000 Pieces /Year Product Description Vibrator for Women Best Factory Wholesale Directly: We
2.Compared to normal plastic packing tape that will pollute the environment, biodegradable packing tape environmentally friendly, biodegradable, recyclable. Also, the tape can tear by hand in horizontal direction.·3.Proper thickness: Tape roll is 2.0mil thick, comme...