First, we ensured an adequate assay performance of the DLL3 IHC assay, by testing cell lines with known DLL3 expression as previously described in studies evaluating high grade neuroendocrine lung tumors and cell lines35. We tested 4 FFPE cell pellets from lung cancer cell lines with different ...
Results showed that the maximum tolerated dose (MTD) was not reached in the overall population (n = 107), although 5 dose-limiting toxicities (DLTs) occurred––all reversible––including grade 3/4 cytokine release syndrome (CRS, n = 2), grade 3 confusional state (n...