The approval of two messenger RNA (mRNA)-based COVID-19 vaccines have underscored the remarkable potential of RNA-based therapeutics [1,2,3]. Circular RNA (circRNA) is a covalently closed single-stranded RNA molecule [4, 5]. It is reported to present notable advantages over mRNA, including...
In our previous studies, we have developed an innovative multiple-chain DLL3-targeting Triggering Receptor Expressed on Myeloid Cells 1 (TREM1)/DNAX activation protein of 12kDa (DAP12) CAR structure, which included an anti-DLL3 single chain variable fragment (scFv) sequence, TREM1 hinge, DAP12 ...
Notch is a pleiotropic signaling family that has been implicated in pathogenesis of allergic airway diseases; however, the distinct function of individual Notch ligands remains elusive. We investigated whether Notch ligands, Jagged1 and DLL4, exert diffe