本公开涉及DLK1/MEG3基因座在生长激素腺瘤检测和治疗中的应用,通过识别DLK1/MEG3基因座和/或其表达产物,能够实现对生长激素腺瘤的快速、准确的检测。 二、法律状态 法律状态公告日法律状态法律状态信息 2021-05-21 实质审查的生效 实质审查的生效 2021-04-30 公开 公开 三、权利要求 暂无信息 四、说明书暂无信息...
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet. 2010; 42 :68–71.Wallace C, et al. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet. 2010; 42 (1):68–71. doi...
Temple syndrome as a result of isolated hypomethylation of the 14q32 imprinted DLK1/MEG3 region. Am J Med Genet A. 2016; 170A:170-175.Briggs TA, Lokulo-Sodipe K, Chandler KE, Mackay DJ, Temple IK. Temple syndrome as a result of isolated hypomethylation of the 14q32 imprinted DLK1/...
As located in the same locus, we further analyzed the miRNA clusters in this region, and identified that 61.22% of these miRNAs were significantly down-regulated, implying the silence of the imprinted gene cluster DLK1-MEG3. Overexpression of MEG3 suppressed the proliferation of chordoma cells. ...
Meg3.1和DLK1-INTR1.1基因座位进行SNP检测,并对Callipyge基因进行PCR-RFLP分析.结果表明:Callipyge基因没有发现A→G的突变,但在该位点其上游35bp处检测到1个C→T的突变.在Meg3.1位点附近发现了2个呈紧密连锁的突变,在DLK1-INTR1.1座位附近发现了5个SNP位点.提示,上述绵羊群体在DLK1-GTL2印记化结构域表现丰富的SNP...
Abnormal DLK1/MEG3 imprinting correlates with decreased HERV-K methylation after assisted reproduction and preimplantation genetic diagnosis. Stress 2013;16:689-97.Dimitriadou E, Noutsopoulos D, Markopoulos G, Vlaikou AM, Mantziou S, Traeger-Synodinos J, Kanavakis E, Chrousos GP, Tzavaras T,...
We previously identified an imprinted region on chromosome 14, the DLK1 - MEG3 locus, as being down-regulated in human T2D islets. Here, using targeted epigenetic modifiers, we prove that increased methylation at the promoter of Meg3 in mouse β TC6 β -cells results in decreased transcription...
Epigenetic Regu- lation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets. Cell Metab 2014; 19: 135-45.Kameswaran V, Bramswig NC, McKenna LB, Penn M, Schug J, Hand NJ, Chen Y, Choi I, Vourekas A, Won KJ, Liu C, Vivek K, Naji A, Friedman JR, Kaestner KH...
The Callipyge, Meg 3.1 and DLK1-INTR1.1 loci of DLK1-GTL2 imprinted domain were detected by SNP analysis in four sheep populations.The four populations were Tan sheep(n=89),Texels(n=73),Suffolks(n=70)and Poll Dorsets (n=112).The results showed that a mutation of C to T in the upstr...
Besides, we used pyrosequencing to find that abnormal expression of Dlk1-Meg3 expression were caused by hyper-methylation status of IG-DMR. And methylation status of IG-DMR highly correlated with ET1 concentration and Nitrate concentration, these might be one of the mechanisms for impaired ...