The imprinted DLK1-DIO3 locus at 14q32.1-32.31 holds biological significance in fetal development, whereby imprinting errors are causal to developmental disorders. Emerging evidence has implicated this locus in other diseases including cancer, highlighting the biological parallels between fetal organ and ...
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis. Cell Mol Life Sci. 2013;70(5):795-814.Benetatos L, Hatzimichael E, Londin E, Vartholomatos G, Loher P, Rigoutsos I, Briasoulis E. 2013. The microRNAs within the DLK1-DIO3 genomic region: ...
猪3、4和7号染色体qtl定位及六个候选基因的分离、鉴定 热度: 猪MSTN、CD163基因功能域的单碱基突变研究 热度: 玻璃化冷冻小鼠胚胎对印记基因H19%2fIgf2印记控制区甲基化状态及基因表达量的影响 热度: 猪DLK1DIO3印记域4个候选印记基因的分离及其单等位基因表达分析,猪DLK1DIO3印记域4个候选印记基因的分离及其单...
组织均只表达父本来源的等位基因,即DLKl基因为母系印记基因;(2)MEG3基因在初生1 日龄猪的肌肉、心、肝、脾、肺、肾、胃、小肠和脂肪组织中均只表达母本来源的等位基因, 即猪MEG3为父系印记基因;(3)RTLl基因在猪初生1日龄、1月龄和2月龄三个生长发育 ...
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012; 44:398-405. [PubMed: 22387999]Stadtfeld, M.; Apostolou, E.; Ferrari, F.; Choi, J.; Walsh, R.M.; Chen, T.; Ooi, S.S.; ...
The Dlk1-Dio3 locus is among the few imprinted domains controlled by a paternally methylated ICR. The unmethylated maternal copy activates imprinted expression early in development through an unknown mechanism. We find that in mouse embryonic stem cells (ESCs) and in blastocysts, this function is ...
expressionandsubsequentlytheimprintingdefectattheDlk1-Dio3locus.Here,weshowthat germ-cellmarkerDppa3ispresentonlyinlg-iPSCsandhg-iPSCs,andthatinductionwith exogenousDppa3enhancesreprogrammingkinetics,generatingallhg-iPSCs,similarto vitaminC(Vc).Conversely,Dppa3-nullfibroblastsshowreprogrammingblockatpre-iPS...
Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines.doi:10.1186/scrt535Pluripotent stem cells are increasingly used to build therapeutic models, including the transplantation of neural progenitors ...
MicroRNAs in the delta-like 1 homolog-deiodinase, iodothyronine 3 (DLK1-DIO3) cluster have been shown to be critical for embryonic development and epithelial to mesenchymal transition (EMT). DLK1-DIO3 cluster miRNAs are elevated in the serum of patients with metastatic cancer. However, the biolog...
The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. 来自 学术范 喜欢 0 阅读量: 10 作者:S Labialle,V Marty,ML Bortolin-Cavaillé,M Hoareau-Osman,JP Pradère,P Valet,PGP Martin,J Cavaillé ...