No study has previously used pyrosequencing to quantify DNA methylation levels of thegene; while the quantitative methylation levels among CpG sites within a gene may be correlated. To deal with the correlated measures among three CpG sites within thegene, this study analyzed DNA methylation levels ...
The gene encoding SAPAP2, DLGAP2, maps to human Anti-DLGAP2抗体chromosome 8. Consisting of nearly 146 million base pairs, chromosome 8 encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital...
Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol ...
Dlgap2, which encodes one of the main components of scaffold proteins in postsynaptic density (PSD), has been addressed as a candidate gene in autism spectrum disorders. To elucidate the disturbance of synaptic balance arising from Dlgap2 loss-of-function in vivo, we thus generated Dlgap2??
Positional cloning and characterisa- tion of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation. Eur J Hum Genet 2000;8:381-4.Ranta S, Zhang Y, Ross B, Takkunen E, Hirvasniemi A, de la CA, Gilliam TC, Lehesjoki AE (2000) Positional cloning and ...
Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Mol. Autism 5, 32. http://dx.doi.org/10.1186/2040-2392-5-32.Jiang-Xie LF; Liao HM; Chert CH;.Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive ...
Given the differential risk of type 1 diabetes (T1D) in offspring of affected fathers versus affected mothers and our observation that T1D cases have differential DNA methylation near the imprinted DLGAP2 gene compared to controls, we examined whether methylation near DLGAP2 mediat...
Further Evidence for DLGAP2 as Strong Autism Spectrum Disorders/Intellectual Disability Candidate Genedoi:10.4172/2165-7890.1000197Hélène PoquetLaurence FaivreSalima El ChehadehAnne-Laure Mosca-BoidronOMICS International
Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol ...
Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in spermCannabisspermDNA methylationautismheritabilityParental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted ...