At the interim analysis, 30 response-evaluable patients treated with 20 mg lenalidomide were enrolled, and 18 responders (60%) were observed. The results were reviewed by a review committee comprising the Sponsor (the ...
Diffuse large B-cell lymphoma (DLBCL) represents a prevalent malignant tumor, with approximately 40% of patients encountering treatment challenges or relapse attributed to rituximab resistance, primarily due to diminished or absent CD20 expression. Our p
Respondents working in a university hospital more frequently refrain form full-dose chemotherapy with curative intent compared to respondents working in tertiary medical teaching hospitals or general hospitals. Patients without a relevant medical history are generally treated with curative intent irrespective ...
have occurred with ADCETRIS. Monitor patients during infusion. If an IRR occurs, interrupt the infusion and institute appropriate medical management. If anaphylaxis occurs, immediately and permanently discontinue the infusion ...
and febrile neutropenia. Cytokine release syndrome (CRS) was mostly low-grade and predominantly occurred after the first full dose. The overall response rate among response-evaluable patients was 75 percent, with complete metabolic responses in 58 percent and partial responses in 17 percent of partici...
213658_atBE858194SEQ ID NO: 1mRNA full length insert cDNA3.70E−08 clone EUROIMAGE 826033 213748_atAW271713TRIM66tripartite motif-containing 663.30E−05 214891_atU79257FBXO21F-box protein 214.90E−05 218205_s_atNM_017572MKNK2MAP kinase interacting serine/threonine kinase 26.50E−05 ...
Full size image MNKs are regulated by p38 and not ERK in DLBCL Two isoforms of each MNK have been identified in human; the longer isoforms, termed MNK1a and MNK2a, contain the MAPK-binding site in the C terminus, which allows binding and activation of MNKs by either ERK or p38 MAPKs...
Respondents working in a university hospital more frequently refrain form full-dose chemotherapy with curative intent compared to respondents working in tertiary medical teaching hospitals or general hospitals. Patients without a relevant medical history are generally treated with curative intent irrespective ...