In phase 2, patients with relapsed/refractory non-germinal centre B-cell–like DLBCL received oral ibrutinib 560 mg once daily and oral lenalidomide 20 mg or 25 mg once daily on Days 1–21 of each 28-day cycle ...
12 Three years later, 40% of the patients were still in CR.13,14 These results are [comparable to those seen with] CAR T-cell therapy but in a different population, because these were mostly second-line patients. [To receive] CAR T-cell therapy, patients have to be in the third line...
19. In xenograft models of DLBCL, lenalidomide demonstrated major clinical activity on ABC-subtype, in which there was downregulation of B-cell receptor-dependent NF-kB through an inhibition of the transcription factor interferon
19. In xenograft models of DLBCL, lenalidomide demonstrated major clinical activity on ABC-subtype, in which there was downregulation of B-cell receptor-dependent NF-kB through an inhibition of the transcription factor interferon