One of the inducible pathogenesis-related genes is Disease Resistance Response-206 (DRR206), whose role in vivo was unknown. DRR206 is, however, related to the dirigent protein (DP) family. In this study, its biochemical function was investigated in planta, with the metabolite associated with...
Mitochondrial Lon-induced mitophagy benefits hypoxic resistance via Ca2+-dependent FUNDC1 phosphorylation at the ER-mitochondria interface Ananth Ponneri Babuharisankar , Cheng-Liang Kuo & Alan Yueh-Luen Lee Article 11 March 2023 | Open Access STOML2 restricts mitophagy and increases chemosensitivit...
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, resulting in activation of the unfolded protein response (UPR) that aims to restore protein homeostasis. However, the UPR also plays an important pathological role in many diseases, including metabolic disord...
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, an...
The evolution and aggregation of amyloid beta (β) oligomers is linked to insulin resistance in AD, which is also the major characteristic of type 2 diabetes (T2D). Being physically inactive can contribute to the development of AD and/or T2D. Aerobic exercise training (AET), a type of ...
For instance, Diacylglycerol induces insulin resistance through activation of Protein kinase C epsilon type enzyme (PKC-ε) and decreased insulin receptor (IRS-2) tyrosine phosphorylation. Ceramide is a key molecule in sphingolipid metabolism, insulin resistance, and metabolic dysregulation [56,57,58,...
HRAS is a proto-oncogene that encodes the H-ras small GTPase protein, which regulates the cell cycle in response to growth factor stimuli by activating a signaling cascade that leads to cell growth and division [50,51]. HRAS is considered to be one of the most frequently mutated genes in ...
[50]. Alpha-amylase/trypsin inhibitors – molecules conferring pest resistance in wheat – also seem to play a key role in CD innate immune response by engaging the Toll-like receptor 4–MD2–CD14 complex with subsequent up-regulation of maturation markers and release of proinflammatory cytokines ...
Considering a tendency to exercise-induced myalgia in CCD, exercises involving a high-resistance load have to be approached with caution and are probably not recommendable. If complications such as congenital dislocation of the hips (CDH), talipes equinovarus or scoliosis are present at birth or ...
[55], which were earlier discussed as ABI1 proximal interactors. Furthermore, p130Cas-related protein breast cancer anti-estrogen resistance protein 3 (BCAR3), which is also an interactor of CDC42, was labeled as ABI1 proximal interactor (Fig. 2AB) [6]. ABI1 is essential to initiate ...