PPP2R2B Variant Reduces Protein Phosphatase 2A (PP2A) Complexity and Worsens Diabetic Kidney Disease (DKD) Progressiondoi:10.1681/ASN.2024wmpnkab5Zhengying FangZeguo SunKyung LeeRuijie LiuJohn Cijiang HeAmerican Society of NephrologyJournal of the American Society of Nephrology...
Protein phosphatase 2a (PP2A) has an important role, as it is inhibited by BCR-ABL in BC cells by the post-transcriptional upregulation of SET, a phosphoprotein that is frequently overexpressed in other leukaemias and solid tumours. Recent expression profiling of cells from different stages of ...
In human cancer cell lines, TERT physically forms a complex with BRG1, a SWI/SNF-related chromatin remodeling protein, and nucleostemin, a nucleolar GTP-binding protein. The TERT–BRG1–nucleostemin complex drives tumor-initiating cell formation by regulating BRG1 activity rather than contributing d...
PP2A protein phosphatase 2A IL-1β Interleukin-1β IL-6 interleukin-6 TNF-α tumor necrosis factor-α ROS reactive oxygen species NF-κB nuclear factor kappa-B Keywords Alzheimer’s disease Amyloid-β Tau Rho kinase Neuroinflammation Sorry, something went wrong. Please try again and make sure ...
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia Nat Commun, 8 (1) (2017), p. 1679 PubMed PMID: 29162833; PMCID 5698422 10.1038/s41467-017-01834-4 Google Scholar 27 T Grellety, C Callens, E Richard, A Briaux, V Vélasco, M...
[7,38]. Integrin adhesion promotes recruitment of RAC GEF dedicator of cytokinesis protein 1 (DOCK1), breast cancer resistance protein 1 (BCAR1/p130Cas), and CRK, leading to cell spreading and divergent downstream signaling [39]. ABL inhibits this complex formation and resulting cell spreading...
Montine TJ, Cholerton BA, Corrada MM, Edland SD, Flanagan ME, Hemmy LS, Kawas CH, White LR (2019) Concepts for brain aging: resistance, resilience, reserve, and compensation. Alzheimers Res Ther 11:22. https://doi.org/10.1186/s13195-019-0479-y Article PubMed PubMed Central Google Sc...
Malviya, G., Patel, R., Salji, M. et al. 18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy. EJNMMI Res 10, 143 (2020). https://doi.org/10.1186/s13550-020-00728-9 Download citation Received18...
and less than 1% of fatty acids are odd-numbered in plasma. It has been reported that increased C15 and C17 are closely related to insulin resistance, and these are now accepted as biomarkers for type 2 diabetes54. The results obtained from studies that map the lipid distribution of tissues...
select article Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo Research articleOpen access Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo Carrie M. Elks, Peng Zhao, Ryan W...