An integrated structural biology approach encompassing solid-state NMR and molecular dynamics simulations was implemented to obtain an atomic view of the ordered polyglutamine core and fuzzy coat of the amyloid-like protein aggregates implicated in Huntington’s disease. Mahdi Bagherpoor Helabad , Irina...
embryogenesis, wound healing and inflammation [19,57,65,81]. It is a key component of the tumor extracellular matrix (ECM) and is commonly upregulated in cancer. HA primarily interacts with receptor CD44 to initiate a range of pro-cancer signals including enhanced therapy resistance, cell prolif...
Among them, the loss-of-function mutation in the AtNUDT7 gene resulted in enhanced resistance to the infection (Ge et al., 2007). xlg2 is one of the two enhanced disease susceptibility mutants that were found in the screen to be more susceptible to Pst than wild-type (wt) plants. The...
To benchmark the performance of our secondary-structure-based approach, we assessed whether machine learning and template-based methods could also distinguish between fold switchers and single folders in the NusG superfamily. Specifically, we tested AlphaFold28, Robetta43, EVCouplings16, and Phyre217on...
Images are representative of two tissues per group, and enhanced magnifications are shown in the lower panel of each photomicrograph. DB, decidual basalis; Epi, epithelial cells; Str, stromal cells. Scale bars (2 μm) are indicated in the photomicrographs Full size image Pregnant rats exposed...
In recent years, omics tools, such as genomics, transcriptomics, proteomics, metabolomics, and fluxomics, have been increasingly used to expand our understanding of cell physiology and stress resistance, together with improving existing industrial biotech processes. Currently, genomics is widely implemented...
However, defense/stress-responsiveness (TC-rich repeats) only existed in the promoter sequence of SnRK2.9-V, indicating a conservative function of SnRK2.9-V in stress resistance. Consistently, our research demonstrated that there were significantly enhanced tolerance to drought and high salt in SnRK...
Banting lecture 1988: role of insulin resistance in human disease. Diabetes.1988;37:1595-1607.Google Scholar 6. DeFronzo RA. Lilly lecture 1987: the triumvirate: beta-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes.1988;37:667-687.Google Scholar 7. Bergman RN. Lilly ...
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes
The VEGF pathway in cancer and disease: responses, resistance, and the path forward. Cold Spring Harb Perspect Med. 2012;2:a006593. Article PubMed PubMed Central Google Scholar Takahashi T, Shibuya M. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway...