Natural Resistance Associated Macrophage Protein 2 (NRAMP2) refers to an efflux pump that is responsible for exporting iron and other cations from the phagosome. Mutations in the NRAMP2 gene can disrupt its function, leading to the accumulation of iron in the phagosome, which can then be utilize...
Among them, the loss-of-function mutation in the AtNUDT7 gene resulted in enhanced resistance to the infection (Ge et al., 2007). xlg2 is one of the two enhanced disease susceptibility mutants that were found in the screen to be more susceptible to Pst than wild-type (wt) plants. The...
The SARS-CoV-2 spike protein (S) is responsible for receptor binding and membrane fusion. The S protein is composed of two subunits, S1 and S2, which are cleaved by furin protease.4S1 binds with high affinity to the host receptor angiotensin-converting enzyme 2 (ACE2).5S2 forms a hairpi...
Milk proteins and milk protein-derived peptides have been widely studied for their health enhancing properties. This chapter presents the updated scientific knowledge on the bioactive properties of milk protein-derived peptides. The different bioactive p
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes
Enhanced GRK2 protein in breast cells strengthens EGF or heregulin-triggered mitogenic (ERK1/2) and survival (AKT) cascades, fosters proliferation, survival and anchorage-independent growth of luminal MCF7 or MDA-MB-231 basal cancer cells, and increases tumor growth in vivo in xenograft and ortho...
Banting lecture 1988: role of insulin resistance in human disease. Diabetes.1988;37:1595-1607.Google Scholar 6. DeFronzo RA. Lilly lecture 1987: the triumvirate: beta-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes.1988;37:667-687.Google Scholar 7. Bergman RN. Lilly ...
Engineeringenhancedproteindisaggregases forneurodegenerativedisease MeredithEJackrelandJamesShorter* DepartmentofBiochemistryandBiophysics;PerelmanSchoolofMedicine attheUniversityofPennsylvania;Philadelphia,PAUSA ABSTRACT.Proteinmisfoldingandaggregationunderpinseveralfatalneurodegenerativediseases, includingParkinson’sdisease(PD)...
Drug resistance has become a severe challenge for treatment of HIV infections. Mutations accumulate in the HIV genome and make certain drugs ineffective. Prediction of resistance from genotype data is a valuable guide in choice of drugs for effective the
However, defense/stress-responsiveness (TC-rich repeats) only existed in the promoter sequence of SnRK2.9-V, indicating a conservative function of SnRK2.9-V in stress resistance. Consistently, our research demonstrated that there were significantly enhanced tolerance to drought and high salt in SnRK...