doi:WO2005113586 A2Leveillard, ThirrySahel, Jose AlainMohand-said, SaddekPoch, OlivierHicks, DavidAlvarez, CarlosWOWO2005113586A2 * 2005年5月12日 2005年12月1日 Novartis Ag Disease-associated proteins
Roco Proteins and the Parkinson's Disease-Associated LRRK2. Small G-proteins are structurally-conserved modules that function as molecular on-off switches. They function in many different cellular processes with dif... Jingling,Liao,Q Quyen,... - 《International Journal of Molecular Sciences》 被...
while proteins related to DNA repair and HMG proteins are preferentially imported by TNPO2.88Interestingly, TNPO2 enhances export of a large proportion of mRNAs through the formation of a complex with RanGTP and the mRNA export factor NXF1,108suggesting that ...
The interaction of POPDC1 with XIRP1 was confirmed in adult rat heart extracts. Using new monoclonal antibodies specific for POPDC1 and POPDC2, both proteins, together with XIRP1, were found mainly at intercalated discs but also at T-tubules in adult rat and human heart. Conclusions Mutations...
specialist proteins. Intellectual and cognitive function relies on this neural network retaining adaptability, known as neuroplasticity. However, mutations in some of these synaptic proteins can lead to brain dysfunctions and disorders, such as epilepsy or autism. ...
Mouse models that successfully mimic age-dependent neurodegeneration rely mostly on neuronal overexpression of human proteins carrying FAD-causing mutations [41,42]. For instance, 5xFAD mice use the mouseThy1promoter to overexpress human APP harboring three disease-associated mutations (the Florida (I7...
The phenomenon of protein sharing or common antigens between plant hosts and parasites has been interpreted in different ways in attempts to explain the basis of susceptibility of plants to disease or the reason for host specificity of plant pathogens. These views encompass immunogenetic responses, ...
The protein associated with the Gimap5 gene, also Gimap5, is important because it regulates a protein that inactivates an enzyme called GSK3, researchers at the Cincinnati Children say in a news release. "Our data suggest GSK3 inhibitors will improve T cell survival and function and may pre...
Tests in mice have shown that the DNA vaccine reduced accumulation of both types of toxic proteins associated with Alzheimer's disease, namely tau and beta-amyloid, without triggering severe brain swelling that earlier antibody treatments caused in some patients, researchers at the University of Texas...
Protein–protein associations within CD178were queried using the STRING platform37. 176 CD178genes matched with proteins in the STRING database (Fig.4a). Notably, STRING network analysis separated 3 highly connected k-Means clusters within CD178: (A) with 10 proteins (A10); (B) with 8 prote...