Our computational approach has increased the likelihood that alcoholic liver disease is an amyloid-related condition, in which KRT8 aggregation is associated with pathology. The same general procedure that led us to this conclusion could possibly be followed to discover other diseases in which amyloids...
Visiting the ER: the endoplasmic reticulum as a target for therapeutics in traffic related diseases. Adv. Drug Deliv. Rev. 59, 759–781 (2007). Article CAS Google Scholar De Matteis, M. A. & Luini, A. Mendelian disorders of membrane trafficking. N. Engl. J. Med. 365, 927–938 (...
The effects of progressive deterioration of protein homeostasis are thought to play a role in age-related neurodegenerative diseases. The presence of protein aggregates in the brain is namely a hallmark shared by several neurodegenerative diseases, including Parkinson’s (PD), Alzheimer’s (AD) and ...
Proteins associated with various human diseases are enriched in intrinsic disorder. These disease-associated IDPs and IDRs are real, abundant, diversified, vital, and dynamic. These proteins and regions comprise the disease-related unfoldome, which covers a significant part of the human proteome. Pro...
[30], our binding site predictions can suggest one possible mechanism for such diseases: if a mutation in proteinAoccurs on a motifMthat is predicted to be the binding site to a proteinB, andBis involved in pathways related to the disease, it is likely that the mutation disrupts the ...
The complete list of proteins significantly modulated common to MeT5A and primary MCs is shown in Suppl. Fig. 5, 6. Interestingly, Actin cytoskeleton organization related proteins were similarly downregulated in the two subsets. Fig. 3 Treatment with MS-275 modifies the proteome of mesenchymal-...
PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces ...
29 The biological activities of EDN are related to its RNase activity and involve antiviral properties. However, recent studies indicate several other activities of great interest. Thus, EDN has been added to the growing list of alarmins,30 which are proteins that attract and enhance the ...
Obesity is a major risk factor for many common diseases and has a substantial heritable component. To identify new genetic determinants, we performed exome-sequence analyses for adult body mass index (BMI) in up to 587,027 individuals. We identified rare
Protein-Protein Interactions (PPIs) are fundamental means of functions and signalings in biological systems. The massive growth in demand and cost associated with experimental PPI studies calls for computational tools for automated prediction and underst