aI'm saving that picture 我保存那张图片[translate] aProtein excess is also harmful and may affect risk for osteoporosis, heart disease, cancer and gout. 蛋白质剩余也是有害的,并且也许影响风险为骨质疏松症、心脏病、癌症和痛风。[translate]
Model of protein nuclear import and export. Imported cargoes containing nuclear localization signals (NLSs) form complexes with importins in the cytoplasm, enter the nucleus through the NPC, and are dissociated from the importins with the aid of RanGTP. Nuclear export of cargoes starts with the ...
It should be noted that although our study showed that blocking the TLR9-mediated IL-12p40 response ameliorated brainstem encephalitis caused by severe EV71 infection in a mouse model, it is likely that the IL-12p40 response plays a dual role during the infection. Therefore, future studies ...
initiating an essential anticoagulant pathway [238,239,240]. Thrombosis is the formation of a blood clot within a blood vessel caused by cytokines and other inflammatory mediators
Excess SFA accumulates in the ER and induces ER stress, which in turn induces the transcription factor CHOP and mediates the onset of JNK. CHOP not only interacts with activated c-jun to upregulate the transcription of the pro-apoptotic BH3 protein, PUMA but also increases the expression of ...
The importance of Fe/S protein biogenesis is underscored by severe and frequently lethal mitochondrial ‘Fe/S diseases’ with complex metabolic, haematological and neurological phenotypes caused by genetic mutations of the various ISC genes [40,[45], [46], [47], [48], [49]]. The assembly ...
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, resulting in activation of the unfolded protein response (UPR) that aims to restore protein homeostasis. However, the UPR also plays an important pathological ro
It was shown that experimentally created nicotinamide deficiency caused dopamine reduction, cell loss, and consequently parkinsonism90. It was also reported that elevated levels of nicotinamide N-methyltransferase reduces nicotinamide level and consequently Complex I activity in idiopathic PD89. Vitamin D ...
dietary factors (fructose and sugar), oxidative stress, mitochondrial dysfunction, inflammation, endoplasmic reticulum stress, intestinal flora imbalance, and epigenetics [11]. Among them, liver fat accumulation, which may be caused by obesity and insulin resistance, still remains to be the “first hi...
At present, besides Pompe disease, there are two disorders in the muscle which are associated with primary defects in lysosomal proteins (Malicdan et al., 2008), namely Danon (MIM #232300), caused by the deficiency of a membrane bond lyosomal protein LAMP-2, and another disorder with promin...