Past experiments using potting soil and play sand show high adherence values to human cadaver skin over cotton sample; the same scenario would be expected for clay. This data set can be used to improve estimates of dermal exposure to dioxins found in ball clays often used by artisans in the...
Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity no data available Reproductive toxicity no data available STOT-single exposure no data available STOT-repeated exposure no data available Aspiration hazard ...
A precise etiology for CHD remains elusive, but likely results from interactions between genetic and environmental factors during development, when the heart adapts to physiological and pathophysiological conditions. Further, it has become clearer that early exposure to toxins that do not result in ...
The most toxic dioxin is a compound called 2,3,7,8-tetrachlorodibenzo-p-dioxin, or TCDD. In 1976, an industrial explosion in Seveso, Italy, released 20 kilograms of dioxins into the atmosphere, causing the highest known exposure of any population to TCDD. Skin lesions similar to burns appear...
Dow also is funding or supports additional studies that will provide answers to dioxin-related issues. For example, in the Great Lakes Bay Region, Dow has provided unrestricted grants to Michigan’s leading universities to allow them to conduct a broad array of human health exposure and environmen...
The most obvious health effect in humans for exposure to CDDs is chloracne, a severe skin disease characterized by follicular hyperkeratosis (comedones) occurring with or without cysts and pustules.2–4 Unlike adolescent acne, chloracne may affect almost every follicle in an involved area, and it...
Maternal Exposure to a Low Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Suppressed the Development of Reproductive Organs of Male Rats: Dose-Dependen... To assess the health risks associated with exposure to 2,3,7,8-tetrachlorodebenzo-p-dioxin (TCDD), we studied the effects of a ...
kidney, gut, gas bladder, skin, and blood vessels, did not indicate any significant pathology below the LC,,g50. P4501AI mRNA levels in whole 91-d postspawn free embryos from the 84 pg TCDD per gram egg treatment were 2.8 timeshigher compared with control or 41-pg TCDD per gram egg ...
Dow also is funding or supports additional studies that will provide answers to dioxin-related issues. For example, in the Great Lakes Bay Region, Dow has provided unrestricted grants to Michigan’s leading universities to allow them to conduct a broad array of human health exposure and environmen...
Previous rat studies have demonstrated the ability of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)) exposure to promote the epigenetic transgenerational inheritance of disease susceptibility in subsequent generations. The types of disease previously observed include puberty abnormalities, testis, ...