PCB Dioxin Hyperpigmentation Chloracne Occupational exposure Skin cancerPolychlorinated biphenyls (PCB) are well known persistent and toxic environmental pollutants. Our aim was to identify effects of moderate-high exposure to dioxin-like (dl) and non-dioxin-like (ndl)-PCBs on the skin in order to ...
Subgroup analysis suggested that higher external exposure and blood level of TCDD were both significantly associated with the mortality caused by non-Hodgkin’s lymphoma. In conclusion, external exposure and blood level of TCDD were both significantly associated with all cancer mortality, especially for...
Exposure to dioxins is known to increase the risk of cancer and can cause severe reproductive and developmental problems. The most toxic dioxin is a compound called 2,3,7,8-tetrachlorodibenzo-p-dioxin, or TCDD. In 1976, an industrial explosion in Seveso, Italy, released 20 kilograms of dioxin...
exposure todioxin. Other targets of toxicity include the liver, kidney, gastrointestinal tract, and immune system, especially thymic effects. Some dioxins may cause cancer. The mode of toxicity is complex and not fully understood. There is no known use for dioxins and they have no commercial ...
Distribution. The major storage sites are liver and adipose tissue. The skin can act as an important storage site, and high concentrations can also be found in the adrenals (1). After one day of exposure for rats, mice, hamsters and guinea pigs, 25–70% of the dose was stored in the...
The study population (exposed and non-exposed) has been followed up for mortality and cancer incidence as a unique cohort, with the same methods, blinded of the exposure status. Persons who moved outside the study area were nonetheless traced with a higher than 99% success rate [11]. Cance...
2024), and various subtypes of influenza viruses (House et al. 1990; Burleson et al. 1996; Bohn et al. 2005), the exposure to TCDD enhanced morbidity or mortality of infected mice. TCDD also induces an enhancement of virus replication in different cell lines, during infection with MHV in ...
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) SPEC. HAZ.SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid conta...
Health problems occurring in the Vietnamese population due to Agent Orange exposure include mental disabilities, birth defects, high rates of miscarriages, stillbirths, skin diseases, hernias and cleft palates. The link between Agent Orange and cancer is also thought to be strong. Studies show ...
Adverse effects elicited by exposure to toxic substances are not only influenced by the dose, route of administration, and exposure duration but also genetic, epigenetic, and other systemic factors. Cellular responses to xenobiotic insults are essential to minimize damage and ensure survival. Adaptive ...