The objective of the present study was to systematically assess the association between dioxin/2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and cancer incidence and mortality. Systematic literature searches were conducted until July 2015 in Pubmed, Embase and Cochrane library to identify relevant studie...
Absorption. TCDD is retained in all tissues. The highest retention is in fat and liver. Penetration values into human skin are low. For example, a dose of 6.5 ng/cm2 in acetone gave a rate of 5 g/cm2/h. Transfer to the fetus has been observed (43). Absorption rates after single ...
The McArdle Laboratory for Cancer ResearchJournal of Investigative DermatologyPoland A, Knutson JC, Glover E. Histologic changes pro- duced by 2, 3, 7, 8-tetrachlorodibenzo-p -dioxin in the skin of mice carrying mutations that affect the integment. J Invest Dermatol 1984;83:454 A/9....
Dioxin is a persistent environmental pollutant and potent carcinogen, which is primarily found in food, particularly animal fats, and is linked to a number of diseases including type 2 diabetes, heart disease, and skin disorders (Travis and Hattemer-Frey, 1991; Marinkovic et al., 2010). Dioxin...
Some of these veterans reported skin rashes (chloracne), cancer, psychological symptoms, birth defects in their children, and other health issues (IOM, 2020). Agriculture crops and inhabited villages were also sprayed, resulting in the exposure of Vietnamese residents. Many of them continue to ...
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak...
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells. 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) and 12-O-tetradecanoylphorbol-13-acetate (TPA) are both tumor promoters which act through ...
Tetrachlorodibenzo-p-dioxin (TCDD) is classified as a human carcinogen and exerts toxic effects on the skin (chloracne). Effects on reproductive, immunolog... Cliona,M.,McHale,... - 《Toxicology》 被引量: 53发表: 2007年 [Effects of dioxins on the reproduction and development in mammals and...
andTRsignaling pathways[137–139]. A study with the co-incubation of TCDD and T3in normal and cancer human hepatic cells revealed that T3augmented TCDD-inducible AhR-dependentluciferaseactivity in a dose-dependent manner suggesting transcriptional crosstalk between AhR and TR[140]. The...
It has been suggested that dioxins cause skin disorders and liver damage, as well as adverse reproductive effects, cancer, and neurodevelopmental disorders (Institute of medicine, 2008; Nishijo et al., 2014; Tai et al., 2016). In addition, our recent findings suggest that dioxin exposure ...