Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling - Brummer, Shaw, et al. - 2002 () Citation Context ...ver, unlike MEK, inhibition of c-Raf had little or no effect on BCR-induced MEK phosphorylation, although complementation by B-...
Also, in cancer cell proliferation, apoptosis, invasion, and migration abnormal expression of piRNAs are emerging as a crucial regulator hence the role of few piRNAs is being given. Both tRFs and tiRNAs play important roles in tumorigenesis and are promising diagnostic biomarkers and therapeutic ...
Translational Psychiatry www.nature.com/tp ARTICLE OPEN I, robot: depression plays different roles in human–human and human–robot interactions Dandan Zhang 1,2 ✉, Junshi Shen1, Sijin Li1, Kexiang Gao1 and Ruolei Gu 3,4 ✉ © The Author(s) 2021 Socially engaging robots have been ...
The roles of FGFRs in vertebrate development have been examined extensively in several species using either or both of mutants and the gene knockdown approach to reveal common and unique functions of the fgfr genes (Xu et al., 1999 and references therein; Scholpp et al., 2004, Yokoi et al...
36.Rufini A, Tucci P, Celardo I, Melino G. Senescence and aging: the critical roles of p53. Oncogene. 2013; in press. 37.Sepe S, Payan-Gomez C, Milanese C, Hoeijmakers JH, Mastroberardino PG. Nucleotide excision repair in chronic neurodegenerative diseases. DNA repair. 2013; 12:568-...
The evenings culminate with an impressive fireworks display. There is also significant support for the Air Festival from the armed forces with the RAF, Navy and Army each having their own villages on the seafront to promote their activities to the public. 展开 年份: 2023 ...
However, little emphasis has been made on comparison of individual roles of RalA and RalB and their downstream partners in tumor progression. Here we compared the influence of constitutively active RalA and RalB expression on tumor progression. We showed that both active Ral proteins enhanced ...
Cancer cells are able to uptake extracellular ATP (eATP) via macropinocytosis to elevate intracellular ATP (iATP) levels, enhancing their survival in drug treatment. However, the involved drug resistance mechanisms are unknown. Here we investigated the roles of eATP as either an energy or a phosp...
Excision of the initiator methionine is among the first co-translational processes that occur at the ribosome. While this crucial step in protein maturation is executed by two types of methionine aminopeptidases in eukaryotes (MAP1 and MAP2), additional roles in disease and translational regulation ...
Climate changes leading to increasingly longer seasonal drought periods in large parts of the world increase the necessity for breeding drought-tolerant crops. Cultivated potato (Solanum tuberosum), the third most important vegetable crop worldwide, is r