FULL PAPER British Journal of Cancer (2017) 117, 315–321 | doi: 10.1038/bjc.2017.178 Keywords: colorectal cancer; primary tumour location; sidedness; cetuximab; EGFR gene copy number; EGFR promoter methylation; RAS; BRAF The role of primary tumour sidedness, EGFR gene copy number and EGFR ...
Although many high-frequency mutant genes such as TERT, TP53, CTNNB1, and KRAS have been confirmed in PLC, it is still not clear whether they play the role of “driver gene” or “passenger gene” in the progression of liver cancer, which limits the development of targeted drugs. There ...
Abnormal activation of intracellular signaling play a critical role in cancer development and progression. Our aim was to elucidate mechanisms underlying the higher oncogenic potential attributed to AA variant. We evaluated activation of MAPK and PI3K/AKT pathways in primary human keratinocytes (PHKs) ...
(1997) The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: the role of telomerase reactivation, Eur. J. Can. 33, 727-734. Article CAS Google Scholar Popovic, M., Lange-Wantzin, G., Sarin, P.S., Mann, D. and Gallo, R.C. (1983) ...
Objective To investigate the incidence of primary graft dysfunction(PGD)after liver transplantation from donation after cardiac death(DCD)and the risk fact... T Wang,Y Jiang,M Xie,... - 《Acta Academiae Medicinae Qingdao Universitatis》 被引量: 0发表: 2017年 The role of nitric oxide in prima...
Here we show, by combining loss- and gain-of-function studies in breast cancer cells, mammary epithelial cells and mouse models, that endogenous R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma. R-Ras2 drives ...
The role of various parathyroid hormone (PTH) radio-immunoassays in the diagnosis of primary hyperparathy-roidism (PHP) is controversial. A series of 204 patients with surgically proven PHP was studied. Serum total calcium, serum ionized calcium, amino ( N )-terminal PTH and carboxyl( C )-...
a充当次级生产者的角色, Plays the secondary producer's role, [translate] aThe prime intention of this article is to remind central government list resource recycling industry in the important agenda. This article’s primary intention, lies in reminds the government the regeneration resources recycling...
Nevertheless, the role of 1O2 is debatable because it has been considered as a non-selective radical (Zhou et al., 2017). The incorporation of MPzs to the photocatalysts could promote the formation of active sites and the glucose adsorption, therefore accelerating the glucose oxidation. HPW ...
Mulagenesis of truncated AK liagments indicates that a region in the NII,-terminal domain is required for Kr\F lo enhance IZR-DNA binding T h e interaction of RAF u,itli AR arid G R suggests that RAI: might influence the ability o f these nuclear receptors to acllvatc transcri~lion ...