FULL PAPER British Journal of Cancer (2017) 117, 315–321 | doi: 10.1038/bjc.2017.178 Keywords: colorectal cancer; primary tumour location; sidedness; cetuximab; EGFR gene copy number; EGFR promoter methylation; RAS; BRAF The role of primary tumour sidedness, EGFR gene copy number and EGFR ...
Abnormal activation of intracellular signaling play a critical role in cancer development and progression. Our aim was to elucidate mechanisms underlying the higher oncogenic potential attributed to AA variant. We evaluated activation of MAPK and PI3K/AKT pathways in primary human keratinocytes (PHKs) ...
Funding/Support: This study received financial support from the University of Chicago. Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript...
The role of nitric oxide in primary graft dysfunction after livertransplantation Author information: (1)Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Scotland, UK. J.,de,Jonge,... - 《Journal of Hepatology》 被引量: 3发表: 2000年 RISK FACTORS FOR PRIMARY GRAFT DYSFUNCTION AFTER...
Nevertheless, the role of 1O2 is debatable because it has been considered as a non-selective radical (Zhou et al., 2017). The incorporation of MPzs to the photocatalysts could promote the formation of active sites and the glucose adsorption, therefore accelerating the glucose oxidation. HPW ...
Here we show, by combining loss- and gain-of-function studies in breast cancer cells, mammary epithelial cells and mouse models, that endogenous R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma. R-Ras2 drives ...
(2010) Role of Erythropoietin Receptor Signaling in Parvovirus B19 Replication in Human Erythroid Progenitor Cells. J Virol 84: 12385–12396. [25] Lodish HF, Ghaffari S, Socolovsky M, Tong W, Zhang J (2009) Intracellular signaling by the erythropoietin receptor. In: Elliott SG, Foote MA, ...
others assumed a more involved role of the PCP with training in biopsies, procedures, and other treatments. Dermoscopy was included in 38% of the programs. Dermoscopy training for family physicians has been shown to increase the sensitivity for melanoma detection versus naked eye examination with no...
Together with the observation that perturbation of the MRE11/NBS1/RAD50 complex predisposes to cancer, our work highlights MRE11 as a new common target in the MMR deficient tumorigenesis and suggests its role in colorectal carcinogenesis. 展开 ...
The role of various parathyroid hormone (PTH) radio-immunoassays in the diagnosis of primary hyperparathy-roidism (PHP) is controversial. A series of 204 patients with surgically proven PHP was studied. Serum total calcium, serum ionized calcium, amino ( N )-terminal PTH and carboxyl( C )-...