Diagnosis of acute promyelocytic leukemia by RT-PCR detection of PML/RARa and RARa /PML fusion transcript, Br. J. Haematol ., 82 (1992) 529–540.Borrow J, Goddard AD, Gibbons B, Katz F, Swirsky D, Fioretos T, Dube I, Winfield DA, Kingston J, Hagemeijer A, Rees JKH, Lister TA,...
Spotlight on the Diagnosis of Acute Promyelocytic Leukemia (AML-M3) Using Karyotyping, FISH and Quantitative Real-Time PCRObjective: This study aimed to confirm the diagnosis of AML-M3 and the frequency of occurrence of the breakpoint cluster region (bcr1) in patients provisionaly diagnosed ...
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), classified by a translocation between chromosomes 15 and 17 [t(15;17)], that is considered a true oncologic emergency though appropriate therapy is considered curative. Therapy is often initiated on clinical suspicion...
(15;17); APL; immunobead; flow cytometry INTRODUCTION The presence of t(15;17) with the PML–RARA fusion gene is considered to be the hallmark of acute promyelocytic leukemia (APL), also known as acute myeloid leukemia (AML) type M3.1 Initially t(15;17) was assumed to be present in ...
Acute Myeloid Leukemia Acute Promyelocytic Leukemia (APL) Overview An Overview of Juvenile Myelomonocytic Leukemia CD Markers in Cancer Diagnosis and Treatment Differentiation in Cell Development An Overview of Chronic Lymphocytic Leukemia FISH Tests for Diagnosing Cancers ...
Diagnosis of acute promyelocytic leukaemia by RT‐PCR: detection of PML‐RARA and RARA‐PML fusion transcripts Summary. Acute promyelocytic leukaemia (APL; AML M3) is identified by a unique t(15;17) translocation which fuses the PML gene to the retinoic acid receptor alpha gene ( RARA ). ...
The PML-RARA fusion protein is found in approximately 97% of patients with acute promyelocytic leukemia (APL). APL can be associated with life-threatening bleeding complications when undiagnosed and not treated expeditiously. The PML-RARA fusion protein arrests maturation of myeloid cells at the promy...
2) acute promyelocytic leukemia/diagnosis 急性早幼粒细胞白血病/诊断3) granulocytic/diagnosis 粒细胞/诊断4) X-linked sideroblastic anemia 遗传性铁粒幼细胞贫血 1. X-linked sideroblastic anemia (XLSA) is caused by mutations of erythr oid-specific 5-aminolevulinate synttase (ALAS2) gene. X...
Acute Promyelocytic Leukemia: A Paradigm for Differentiation Therapy treatment of acute leukemia, highlighting the potential of molecularly targeted and MRD-directed therapies to achieve an individualized approach to patient ... D Grimwade,AR Mistry,E Solomon,... - 《Cancer Treat Res》 被引量: 752...
Certain subgroups of acute nonlymphocytic leukemia (ANLL), such as acute promyelocytic leukemia and erythroleukemia, have been distinguished as morphologic and clinical entities.1,2 This report describes ten patients with a form of ANLL in which the leukemic cell population consists of primitive-...