Background: This study aimed to evaluate the impact of rapid genetic testing (RGT) for BRCA1 and BRCA2 at the time of breast cancer diagnosis on treatment choices. Bilateral mastectomy for the treatment of breast cancer in women with a BRCA1 or BRCA2 mutation offers a reduction i...
Health care segregation, physician recommendation, and racial disparities in BRCA1/2 testing among women with breast cancer. J Clin Oncol. 2016;34(22):2610-2618. doi:10.1200/JCO.2015.66.0019PubMedGoogle ScholarCrossref 17. Dharwadkar P, Greenan G, Stoffel EM, et al. Racial...
There is also information on breast cancer gene (BRCA) status and FOXP1, where negativity for FOXP1 was associated with a significantly worse OS in BRCA2 cancers [94]. However, recent reports suggest FOXP1 as an oncogene in ER− BC [93, 95]. 3.3 CTLA-4: A Key Actor in Cancer ...
Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab therapy with multi-course treatment, and 90...
for training, validation, and testing, respectively (Supplementary Table1). The validation dataset was adopted to perform parameter studies while the test dataset was utilized to perform comparative studies with other approaches. Third, to generate simulated cfDNA methylation profiles for cancer patients,...
IVD for the first time in Asia, detected BRCA1/2 gene mutations at once, provided optimal and personalised treatment methods to patients through NGS diagnosis and genetic testing. It is designed to apply and automatically analyse the NGS data produced from test reagents and issue a c...
Age at diagnosis as an indicator of eligibility for BRCA1 DNA testing in familial breast cancer. Hum Genet 1995; 95: 539-44.Cornelis RS, Vasen HFA, Meijers-Heijboer H, Ford D, van Vliet M, van Tilborg AAG, Cleton FJ, Klijn JGM, Menko FH, Meera Khan P, Cornelisse CJ, Devilee P:...
Hurley K, Rubin LR, Werner-Lin A, Sagi M, Kemel Y, Stern R, Phillips A, Cholst I, Kauff N, Offit K: Incorporating information regarding preimplantation genetic diagnosis into discussions concerning testing and risk management for BRCA1/2 mutations: A qualitative study of patient preferences....
P values were calculated using a two-sided Mann–Whitney U-test and adjusted for multiple testing (Benjamini–Hochberg correction). e, Density of distances between genomic regions and breakpoints detected in ETMR, Ewing sarcoma, random breakpoints and reference breakpoints. f, Total percentage of ...
Gorthi, A. et al. EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.Nature555, 387–391 (2018). ADSCASPubMedPubMed CentralGoogle Scholar Kloosterman, W. P. et al. Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks ...