It explores advancements in induced pluripotent and totipotent stem cells, transcription factor-mediated reprogramming, and stem cell-derived organoids for understanding cell fate transitions, disease modeling, and therapeutic applications. Topics include the molecular basis of cell fate plasticity, ...
the pro-B cell stage9. We found that theEbf1locus moved closer to the nuclear periphery in old pro-B cells (Fig.1h,i). In contrast, theFoxo1locus, encoding a co-regulated factor, did not change its radial position or proximity to heterochromatin-associated γ-satellite repeats in old pro...
Fig. 1: Impact of Id3-deficiency on development of γδ T cell subsets. a, b Representative flow cytometry plots of thymocytes from Id3+/+, Id3+/-, and Id3−/− mice. a Flow cytometry plots of expression of CD24 and the indicated Vγ are displayed for CD4-CD8- thymocytes. b A...
T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces different phenotypes in distinct γδ T cell subsets. Here, we show that Id3 def...
North America dominates the cell line development market over the forecast period. The United States has a better healthcare infrastructure, compared to most developed countries. The presence of key players in the United States is the major factor propelling the growth of the market studied in the...
Tissue-resident immune cells, such as innate lymphoid cells, mediate protective or detrimental immune responses at barrier surfaces. Upon activation by stromal or epithelial cell-derived alarmins, group 2 innate lymphoid cells (ILC2s) are a rapid source
This is consistent with the research that a HFD can induce TrxR1/hTrx1 palmitoylation and negatively impact these two critical antioxidant proteins in mouse liver [78]. Moreover, palmitate induces ER stress in pancreatic β cells, resulting in β cell apoptosis and impaired insulin production in ...
Cells & Developmentis an international journal covering the areas of cell biology and developmental biology. In addition to publishing work at the … Article publishing options Open Access Article Publishing Charge (APC):USD 3,450 (excluding taxes).The amount you pay may be reduced during submissio...
Platelet derived growth factor receptor PLLA: Poly l-lactic acid RA: Retinoic acid SebE6E7: Cell line name SERM: Selective estrogen receptor modulator SFRP2: Secreted frizzled-related protein 2 SHH: Sonic hedgehog SMAD: Drosophila mothers against decapentaplegic protein SSc: Systemic scle...
SDF-1 acts through an activation improvement of EGR-1, and it expands the cell tropism toward the follicle and builds angiogenesis. The activity of MCP-1, despite being an inflammatory factor, has a demonstrated tissue regenerative impact. A critical role of the microenvironment in the impact ...