Covers not only cell biology but also pathology, cytology, oncology, and regenerative medicine. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models are covered as well. Editor-in-Chief Hiroaki Kataoka Journal Impact Factor 3.4 (2023) ...
Major studies on cell production have put the emphasis on technical factors (machine order/ layout, family part grouping, workflow sequence, etc.), it is still insufficient to investigate how human factors affect the efficiency of manufacturing cells.In order to evaluate the impact of human ...
Background: The aim of this study was to test the feasibility and safety of subretinal transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) cells into the healthy margins and within areas of degenerative retina in a swine model of geographic atroph...
Bioinformatic analysis of T cell receptor (TCR) repertoires from 173 recovered COVID-19 patients shows that severe cases under the age of 55 have a compromised TCR repertoire, contributing to poorer outcomes. Key changes include reduced diversity, increased clonality and altered V-allele usage, with...
(a B cell-activation factor)) have also been prominently featured14. In mice, Mcl-1, which is an important negative regulator of apoptosis through BCMA signaling, was found to be essential for BM plasma cell survival15. Other cytokines and chemokines have also been implicated such as IL-5...
We also developed a KO screen using Cas12a with paired crRNAs and identified 75 coPARSE-lncRNAs that functionally impact cancer cell proliferation. Moreover, several prioritized human coPARSE-lncRNAs and their zebrafish homologs were validated to exert common functions in distantly related species. ...
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty 2012, Cancer Cell Citation Excerpt : An important question is whether we have systematically underestimated the frequency of tumorigenic cells by using transplantation assays that have not been optimized to detect the full range of cells with th...
Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1 Immunity, 33 (2010), pp. 229-240 Google Scholar Zwirner and Ziblat, 2017 N.W. Zwirner, A. Ziblat Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL...
TMM normalization method and manually inputted total mapping reads [50]. EdgeR was then used to make a pooled comparison between RNA Polymerases ChIP-seq versus input using cell line as an independent factor. EdgeR analysis yielded the log2 fold changes for ChIP with respect to input and an ...
Cell 169, 1177–1186 (2017). Article PubMed PubMed Central CAS Google Scholar de Lange, K. M. et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat. Genet. 49, 256–261 (2017). Article PubMed PubMed Central CAS ...