Results Among 639 ANA-positive patients, 19.6% displayed the DFS pattern. And 17.6% of patients with the DFS pattern were diagnosed with AARD. The low titer of 1:80 was more prevalent in the non-AARD group than in the AARD group (64.1% vs. 4.5%, p 0.0001). Anti-DFS70 ...
Monospecific anti-DFS70 antibodies are moderately helpful in excluding ANA-associated rheumatic disease in patients presenting with a dense fine speckled p... CF Cheng,T Lan,M Shih,... - 《Autoimmunity Reviews》 被引量: 0发表: 2020年 Antineutrophil cytoplasmic autoantibody-associated alveolar ...
Results:A total of 469 patients (1.27% of patients with positive anti-nuclear antibody indirect immunofluorescence (ANA IIF) test results) revealed the DFS pattern, of which 92.96% had isolated DFS pattern and 23.67% had titers above/equal to 1:320. The average age of patients with the DFS...
The dense fine speckled (DFS) pattern as detected by indirect immunofluorescence (IIF) on HEp-2 cells has been associated with several inflammatory diseases but is most commonly observed in individuals that do not have an antinuclear antibody (ANA)-associated rheumatic disease and...
Audit of dense fine speckled ana patterns detected by indirect immunofluorescence in a clinical immunology laboratorydoi:10.1016/j.pathol.2016.12.333Wade, LucyAcquarola, NickHall, AnneSjollema, PaulO’Sullivan, MichaelElsevier B.V.Pathology
Certain IIF patterns have known antibody and disease associations, but the dense fine speckled (ANA-DFS) pattern has no confirmed clinical associations. Our objective was to determine the prevalence of SARD among a group of ANA-DFS positive individuals and to identify final diagnoses among non-...
Background: In antinuclear antibody (ANA) testing, antidense fine speckled 70 (DFS70) antibodies are commonly detected as a specific indirect immunofluorescence assay pattern (IIFA in HEp-2-based substrates) or as bands/blot lines in immunoblotting. A negative association b...
2007. Relevance of the immunofluorescence pattern for interpretation of the ANA test: the case of the dense fine speckled pattern. Rev Assoc Med Brasil 53: 439-445.Dellavance A; Leser PG,Andrade LE; Relevance of the immunofluorescence pattern for interpre tation of the ANA test-the case of ...
Conclusions According to previous studies, up to 20% of healthy individuals have been reported to have a positive IIF-ANA test and the DFS pattern has been reported in 33% of ANA positive healthy individuals, but not in ANA positive systemic autoimmune diseases. In this study the prevalence ...
In some patients, a pattern can be detected in ANA immunofluorescence that resembles an anti-dense-fine-speckled-70 antibody [2]. This is detected less frequently in patients with connective tissue diseases (CTD) and is therefore often used as an exclusion criteria for a CTD [2]. To date,...