dense fine speckled patternexclusion criterionsystemic autoimmune rheumatic diseasesObjective:To provide information on the prevalence and possible clinical association in a Chinese population for medical practice of the dense fine speckled pattern (DFS pattern). Methods:A retrospective study was conducted ...
Monospecific anti-DFS70 antibodies are moderately helpful in excluding ANA-associated rheumatic disease in patients presenting with a dense fine speckled p... CF Cheng,T Lan,M Shih,... - 《Autoimmunity Reviews》 被引量: 0发表: 2020年 Antineutrophil cytoplasmic autoantibody-associated alveolar ...
We evaluated the potential use of anti-DFS70 antibodies for verifying AARD in patients with a positive ANA result of the DFS pattern. Methods A total of 5509 patients who were requested ANA testing were included. The DFS pattern was confirmed using two IIF assays. Semiquantitative DFS70 ELISA...
The dense fine speckled (DFS) pattern as detected by indirect immunofluorescence (IIF) on HEp-2 cells has been associated with several inflammatory diseases but is most commonly observed in individuals that do not have an antinuclear antibody (ANA)-associated rheumatic disease and...
Certain IIF patterns have known antibody and disease associations, but the dense fine speckled (ANA-DFS) pattern has no confirmed clinical associations. Our objective was to determine the prevalence of SARD among a group of ANA-DFS positive individuals and to identify final diagnoses among non-...
Audit of dense fine speckled ana patterns detected by indirect immunofluorescence in a clinical immunology laboratorydoi:10.1016/j.pathol.2016.12.333Wade, LucyAcquarola, NickHall, AnneSjollema, PaulO’Sullivan, MichaelElsevier B.V.Pathology
Background: In antinuclear antibody (ANA) testing, antidense fine speckled 70 (DFS70) antibodies are commonly detected as a specific indirect immunofluorescence assay pattern (IIFA in HEp-2-based substrates) or as bands/blot lines in immunoblotting. A negative association b...
2007. Relevance of the immunofluorescence pattern for interpretation of the ANA test: the case of the dense fine speckled pattern. Rev Assoc Med Brasil 53: 439-445.Dellavance A; Leser PG,Andrade LE; Relevance of the immunofluorescence pattern for interpre tation of the ANA test-the case of ...
Background The nuclear dense fine speckled (DFS) pattern is one of the most commonly observed finding in indirect immunofluorescence-antinuclear antibody (IIF-ANA) assay on HEp-2 cells. Unlike other ANA, DFS pattern is not prevalent in ANA-associated rheumatic diseases (AARD). The antigen was ...
Human antinuclear autoantibodies (ANAs) targeting the dense fine speckled (DFS) nuclear protein DFS70, commonly known as lens epithelium derived growth factor p75 (LEDGFp75), present a clinical puzzle since their significance remains elusive. While their frequencies are low in ANA-positive autoimmune...