Audit of dense fine speckled ana patterns detected by indirect immunofluorescence in a clinical immunology laboratorydoi:10.1016/j.pathol.2016.12.333Wade, LucyAcquarola, NickHall, AnneSjollema, PaulO’Sullivan, MichaelElsevier B.V.Pathology
Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases The presence of anti-nuclear antibodies (ANA) is a hallmark of systemic autoimmune rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay o... ...
Monospecific anti-DFS70 antibodies are moderately helpful in excluding ANA-associated rheumatic disease in patients presenting with a dense fine speckled p... CF Cheng,T Lan,M Shih,... - 《Autoimmunity Reviews》 被引量: 0发表: 2020年 Antineutrophil cytoplasmic autoantibody-associated alveolar ...
Nuclear dense fine speckled (DFS) pattern, a competent-level pattern evaluated by the ICAP previously (AC-02),2 is frequently discussed in the current recommendation for it being the pattern best associated with apparently healthy individuals, or negatively correlating with systemic autoimmune rheumatic...
The dense fine speckled (DFS) pattern as detected by indirect immunofluorescence (IIF) on HEp-2 cells has been associated with several inflammatory diseases but is most commonly observed in individuals that do not have an antinuclear antibody (ANA)-associated rheumatic disease and...
Among the 30 ANA patterns, homogeneous (AC-1) and dense fine speckled (AC-2) should be focused on owing to their somewhat indistinct presentation in immunofluorescence imaging and distinct correlation with clinical conditions. This study aimed to develop a flowchart to ...
Certain IIF patterns have known antibody and disease associations, but the dense fine speckled (ANA-DFS) pattern has no confirmed clinical associations. Our objective was to determine the prevalence of SARD among a group of ANA-DFS positive individuals and to identify final diagnoses among non-...
Objective:To provide information on the prevalence and possible clinical association in a Chinese population for medical practice of the dense fine speckled pattern (DFS pattern). Methods:A retrospective study was conducted with patients who had the DFS pattern from June 2018 to December 2019 in ...
autoimmune diseasesThe correspondence of Deng et al 1 raises practical issues regarding the recognition and clinical interpretation of the nuclear dense fine speckled (DFS, AC-2) pattern in a typical clinical immunology laboratory during antinuclear antibody (ANA) screening using indirect immunofluorescence...
Background When the dense fine speckled (DFS) pattern-antinuclear antibodies (ANA) are detected in the indirect immunofluorescence (IIF) assay, the presence of anti-dense fine speckles 70 (DFS70) antibodies has been suggested to facilitate the exclusion of ANA-associated rheumatic diseases (AARD)....