Delta-12-Prostaglandin J2(Synonyms: Δ12-PGJ2) Delta-12-Prostaglandin J2 (Δ12-PGJ2) 是一种环戊烯酮前列腺素 (PG),对多种肿瘤细胞的生长具有抗增殖作用。Delta-12-Prostaglandin J2 是前列腺素 D2 的天然脱水产物,能够通过 caspase 激活诱导 HeLa 细胞的凋亡 (apoptosis)。 Delta-12-Prostaglandin J2Ch...
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from delta, twelve-PGJ2-tyrosine-methyl-ester (II) and Na 125I of exceptionally high specific activity. - Application of radio-ligand (I) improved radio-immunological assaying of 9-dezoxy-delta,mine-13,14- di:hydro-prosta-glandin O2 (delta, twelve-PGJ2) content of sample-specimens owing ...
from delta, twelve-PGJ2-tyrosine-methyl-ester (II) and Na 125I of exceptionally high specific activity. - Application of radio-ligand (I) improved radio-immunological assaying of 9-dezoxy-delta,mine-13,14- di:hydro-prosta-glandin O2 (delta, twelve-PGJ2) content of sample-specimens owing ...
PGJ2 and delta 12PGJ2 (1 microM to 30 microM) inhibited the growth of human astrocytoma cells (1321N1) in a time-dependent manner within 48 hrs, determined by [3H]thymidine incorporation into acid-insoluble fraction or amounts of protein. The EC50 values for PGJ2 and delta 12PGJ2 were ...
Oncology 15-Deoxy-Delta 1214-prostaglandin J2 (15D-PGJ2) mediated signaling in colon cancer. THE UNIVERSITY OF ARIZONA Eugene W. Gerner MehtaDipti JhewerchandNormal tissue structure and function are maintained by a dynamic interaction between epithelial cells and the stroma consisting of fibroblasts,...
Kim HJ, Rho YH, Choi SJ, Lee YH, Cheon H, Um JW, Sohn J, Song GG, Ji JD. 15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phos- phorylation in lymphocytes. Exp Mol Med 37: 179 -185, 2005.Kim HJ,Rho YH,Choi SJ,et al.15-Deoxy-delta12,14-PGJ2 inhibits IL-6-...
PEROXISOME PROLIFERATOR ACTIVATOR RECEPTOR-[gamma] (PPAR[gamma]) LIGANDS, 15-DEOXY-[DELTA]12,14- PGJ2 (15D-PGJ2) AND CIGLITAZONE, PROVIDE CARDIOPROTECTION DURING REPERFUSION THROUGH DIFFERENT MOLECULAR MECHANISMS.: 184An abstract is unavailable. This article is available as a PDF ...
15-deoxy-Delta12,14-PGJ2 (15d-PGJ2), a ligand of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), mediates repression of TNFalpha by decreasing levels of acetylated H4doi:10.1016/j.jamcollsurg.2006.05.082Ryan...
Kaplan JM, Cook JA, Hake PW, O’Connor M, Burroughs TJ, Zingarelli B (2005) 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. Shock 24:59–65...