15-deoxy-∆12,14-Prostaglandin J2 is one of the ultimate dehydration products of PGD2. PGD2 is formed from PGH2 which itself is synthesized from arachidonic acid by the enzyme prostaglandin synthase1-4. In the aqueous solution PGD2 forms PGJ25. Albumin or other serum proteins present in ...
英文别名 15-deoxy- delta 12,14-prostaglandin J2 | 15-Deoxy-DELTA(12,14)-PGJ2 | (5Z,12E,14E)-11-oxo-prosta-5,9,12,14-tetraen-1-oate | HMS1361E03 | 15-Deoxy-delta12,14-prostaglandin | BDBM50270612 | HMS1791E03 | (Z)-7-[(1S,5E)-5-[(E)-oct-2-enylidene]-4-oxo-1-cyc...
We investigated the ability of peroxisome proliferator-activated receptor (PPAR)-gamma ligands 15-deoxy-delta12,14PGJ2 (15d-PGJ2), delta12PGJ2, ciglitizone and rosiglitazone to induce apoptosis in the amnion-like WISH cell line. 15d-PGJ2 (10 microM) induced morphological characteristics of ...
suppressor of cytokine signaling Abstract 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a natural li- gand that activates the peroxisom e prolifera- to rs-activated recepto r (P P A R ) γ, a m em ber of nuclear receptor fam ily im plicated in regulation of lipid m etabolism and adipocyt...
The omega-6 fatty acid derivative 15-Deoxy-螖12,14-prostaglandin J2 (15d-PGJ2) is believed to play a role in cellular protection against oxidative stress in diverse cell systems. However, the cellular mechanisms by which protection is afforded by 15d-PGJ2 are not fully elucidated in vascular...
15-Deoxy-Δ12,14-Prostaglandin J2-d9 (15d-PGJ2-d9) 是 15-Deoxy-Δ-12,14-prostaglandin J2 的氘代物。15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) 是一种环戊烯酮前列腺素和 PGD2 的代谢产物。15-Deoxy-Δ-12,14-prostaglandin J2 是一种选择性的PPARγ(EC50为 2 µM) 和共价的 ...
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) 是一种环戊烯酮前列腺素和 PGD2 的代谢产物。15-Deoxy-Δ-12,14-prostaglandin J2 是一种选择性的 PPARγ (EC50 为 2 µM) 和共价的 PPARδ 激动剂。15-Deoxy-Δ-12,14-prostaglandin J2 促进 C3H10T1/2 成纤维细胞向脂肪细胞的有效分化,EC50 为...
15-Deoxy-Delta12,14-prostaglandin J2 alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy. Acta Pharmacol Sin 38, 672-687, doi:10.1038/aps.2016.108 (2017).Chen K, Li JJ, Li SN, Feng J, Liu T, Wang F, Dai WQ, Xia...
15-Deoxy- 12,1412,14-PGJ2 Induces IL-8 Production in Human T Cells by a Mitogen-Activated Protein Kinase Pathway Mast cells, platelets, and some macrophages are abundant sources of PGD(2) and its active metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15-d-PGJ(2)). The lipid ... SG Har...