Delivery of Oligonucleotide Therapeutics for Macrophage Reprogramming in Inflammatory Diseasesdoi:10.1007/978-3-030-84164-5_16Macrophages are one of the most plastic and fascinating cells of the innate immune system. From phagocytosis of invading pathogens and dead cells, maintaining tissue homeostasis, ...
Cancer nanotherapeutics comprise the main application of nanotechnology to healthcare and are administered intravenously for faster action and maximal bioavailability. As nanotherapeutics become more clinically established, a fundamental understanding of
Engineering considerations for next-generation oligonucleotide therapeutics Article 23 December 2024 Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry Article Open access 02 December 2023 References Kim, J. et al. Patient-customized oligonucle...
Single-strand oligonucleotides provide promising potential as new therapeutics towards various diseases. However, the efficient delivery of oligonucleotide therapeutics is still challenging due to their susceptibility to nuclease degradation and the lack
The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression
SMi Group Proudly Presents: Oligonucleotide Therapeutics and Delivery Conference Website: www.oligonucleotide.co.uk/gate2biowl On the way to maximising the potential of oligo-based medicine
Especially in the case of oligonucleotide therapeutics, with great potential to treat many genetic diseases, nucleic acids must be delivered into the cytosol or nucleus; hence, lipid membranes are one of the major barriers in achieving this goal for targeted therapeutic efficacy [8,41]...
Modes of Action of Oligonucleotide and siRNA Therapeutics Types of Oligonucleotide Analogue Strategies For Peptide-Mediated Delivery Peptide Conjugates and Complexes For Antisense Oligonucleotide and siRNA Applications Polymer, Liposomal, and Exosome Delivery Methods Involving Peptides Physiological Aspects of Pept...
Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer t... Cell-selective delivery and sensitivity to serum nucleases remain major hurdles to the clinical application of RNA-based oligonucleotide therapeutics, suc...
Lipid nanoparticles hold great potential as an effective non-viral vector for nucleic acid-based gene therapy. Plasmid DNA delivery can result in extended transgene expression compared to mRNA-based technologies, yet there is a lack of systematic in