We propose that the DNA binding differences between MCM2-7 and MCM467 correspond to a conformational change at the MCM2/5 active site with putative regulatory significance. 展开 关键词: Saccharomyces cerevisiae DNA Helicases Adenosine Triphosphate DNA, Single-Stranded Nucleotides DNA-Binding Proteins ...
Inter- actions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions. RNA Biol (2008) 5:92-103. doi:10.4161/rna.5.2.6069Laraki, G,Clerzius, G,Daher, A,Melendez-Pena, C,Daniels, S,Gatignol, A.Interactions between...
these salivary secretomes are likely to be highly similar to the proteins delivered into plant tissues during interactions with the host, and therefore are predicted to include the entire set of effectors. We focussed on categorisation of the total salivary protein lists, and of the DE ...
SARS-CoV-2 is an enveloped betacoronavirus with positive, single-stranded genomic RNA, and is the causative agent of COVID-19. Our understanding of molecular events responsible for the expression of coronavirus proteins has recently been extended to SARS-CoV-21,2,3,4. However, knowledge of the...
AR1 and BR1 have similar nucleic acid binding affinities, suggesting a possible mechanism for the observed effects of the viral coat protein on viral movement. 展开 关键词: Geminiviridae Capsid Plant Leaves Vegetables Viral Proteins DNA, Single-Stranded Base Sequence Phenotype Mutation Suppression, ...
4d,e). PARP1 Y889 is within the drug-binding pocket in the catalytic domain (Fig. 4d) and has been shown to be a critical residue for determining inhibitor specificity over related proteins such as tankryase 1 through van der Waals and pi-interactions with PARP inhibitors60. This ...
coli Cas1/Cas2 proteins were capable of removing 3′ single-stranded DNA overhangs from pre-spacers (Wang et al., 2015) prompted us to hypothesize that, in P. furiosus, Cas4-1 and Cas4-2 may create these overhangs, and Cas1/Cas2 may then carry out the final steps of 3′ DNA ...
NS2B–3181- and NS3181–green fluorescent protein fusion proteins were used to determine the intracellular distribution of the protease complex. The former localized in membrane-based vesicular structures, whereas the latter localized poorly. The data suggest that NS2B–NS3 complex formation requires ...
Krug, L. T., Inoue, N. & Pellett, P. E. Differences in DNA binding specificity among Roseolovirus origin binding proteins. Gulve, N. et al. Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21. ...
FOG proteins have also been shown to interact with the CtBP co-repressor family. Both FOG-1 and FOG-2 have consensus binding sites for CtBP proteins and have been shown to interact with them in vitro (15, 20, 28, 33). However, disruption of this interaction by mutagenesis does not ...