Stem cell purificationCell cycleDifferentiationMurine derived long-term hematopoietic stem cells (LT-HSC) are cycling and thus always changing phenotype. Here we show that over one half of marrow LT-HSC are in the population expressing differentiation epitopes and that B220 and Gr-1 positive ...
Collectively, our data reveal the epigenetic framework that underlies the cell fate options of hematopoietic stem cells. 展开 关键词: Hemoglobin S Glucose-6-Phophate-dehydrogenase Pyruvate Kinase Cabo Verde Malaria DOI: 10.1182/blood-2009-07-235176 被引量: 240 ...
Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci U S A, 100 (2003), pp. 15877-15882 View in ScopusGoogle Scholar 33 Pimanda JE, Silberstein L, Dominici M Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 ...
including analyses of samples from urogenital diseases (kidney transplantation [8], diabetic nephropathy [9], obstructive nephropathy [10], bladder cancer [11], prostate cancer [12], and others) and non-urogenital diseases (hematopoietic stem cell transplantation [13], coronary artery disease [14]...
After generation of a normal epithelial reference, we next aimed to project diseased cells into this subspace, as has previously been done for placing diseased cells isolated from mixed-phenotype acute leukemia samples into the hematopoietic hierarchy25. To accomplish this, we started with the tile ...
BMA = bone marrow aspiration; HSCT = hematopoietic stem cell transplantion; IF = induction failure; LkP = leukapheresis; PB = phlebotomy, UPN = unique patient number. a Dose level 1 = 107 cells/dose; dose level 2 = 108 cells/dose. Vaccine manufacture was successful for all patients (Table...
The signature gene expression profile in TCF3-ZNF384-positive patients was enriched in hematopoietic stem cell features and related to that of EP300-ZNF384-positive patients, but was significantly distinct from that of TCF3-PBX1-positive and ZNF384-fusion-negative patients. However, clinical ...
Bonnet D, Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997, 3 (7): 730-737. 10.1038/nm0797-730. Article CAS PubMed Google Scholar Reya T, Clevers H: Wnt signalling in stem cells and cancer. Nature....
BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis. Cell 2018, 172, 176–190. [Google Scholar] [CrossRef] Ottenhoff, T.H.; Dass, R.H.; Yang, N.; Zhang, M.M.; Wong, H.E.; Sahiratmadja, E.; Khor, C.C.; Alisjahbana, B.; van C...
The equivalents provided will be useful in guiding searches for unrelated hematopoietic stem cell donors in which patients and/or potential donors are typed by either serology or DNA-based methods. These equivalents will also serve typing and matching procedures for organ transplant progrG.M.Th....