ROS scavengers, including superoxide dismutase (Sod1/2) and catalase (Cat), were significantly higher in Zeb1+-LSKs than those in Zeb1−/lowcells (Supplementary Fig.3f, g), suggesting a stronger antioxidant activity that facilitates stem-cell function in Zeb1+-LSKs. To assess whether Zeb1 c...
Human embryonic stem cells (hESCs) derived from the human embryo, and more recently adult dermal fibroblasts induced to be reprogrammed into pluripotent stem cells (hIPCs), represent two potential sources of cells for regenerative cell replacement therapies. However, the fundamental aspects of both ...
We report that HSCs in thalassemic mice (th3) have an impaired function, caused by the interaction with an altered BM niche. The HSC self-renewal defect is rescued after cell transplantation into a normal microenvironment, thus proving the active role of the BM stroma. Consistent with the ...
Hematopoietic stem cell function in viable motheaten mice We have developed an in vitro cell culture model to examine the interaction between connective tissue cells and orthopaedic implant biomaterials. Human connective tissue cells grown on different materials exhibit distinct responses in te... KK ...
stem cell and embryonic stem cell proliferation. However, the role of Cav-1 in hematopoietic stem cell (HSC) function is largely unknown. In this study, we used Cav-1−/−mice to investigate the role of Cav-1 in HSCs function during aging. The results showed that Cav-1−/−mice...
The balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is strictly regulated to sustain blood production throughout adult life. De novo DNA methyltransferase 3-alpha (DNMT3A) is one of the major epigenetic regulators that is essential for efficient HSC differentiation....
hematopoietic stem cells isolated from peripheral blood and cord blood, which are externally cultured and expanded and transplanted to patients for reconstruction or restoration of the hematopoietic function and immune function of the recipient. Currently, hematopoietic stem cell transplantation includes ...
The study of hematopoietic stem cell function in marrow failure syndromes provides hints for specific molecular pathways disturbed in many diseases of hematopoietic and non-hematopoietic stem cells. Beyond the specific interest of investigators involved in the field of these rare diseases, marrow failure...
Author summary Hematopoietic Stem/Progenitor Cell (HSPC) based gene therapy can be used to treat many infectious and genetic diseases. Here, we used an HSPC-based approach to redirect and enhance host immunity against HIV-1. We engineered HSPCs to carry chimeric antigen receptor (CAR) genes that...
1、(P1)Multipotent stromal cells (MSCs) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance. Here, we show that myeloproliferative neoplasia (MPN) progressively remodels the endosteal BM niche int...