What does it mean to say that a gene is 'expressed'? What does no gene flow mean? What is fetal somatic gene therapy? What does cloning a gene mean? How is the Human Genome Project related to gene therapy? Why can't gene therapy use somatic cells? Define epistasis in biology What do...
gene expressiongene set enrichment analysismorphologysurvivalunsupervised cluster analysisBone metastasis is the lethal end‐stage of prostate cancer (PC), but the biology of bone metastases is poorly understood. The overall aim of this study was therefore to explore molecular variability in PC bone ...
(126 new) loci. We map the genotype effect on the methylome in 443 kidneys, transcriptome in 686 samples and single-cell open chromatin in 57,229 kidney cells. Heritability analysis reveals that methylation variation explains a larger fraction of heritability than gene expression. We present a ...
Many members of transforming growth factor-β (TGF-β) superfamily, including not only TGF-β, but also the activins, and bone morphogenetic proteins (BMPs), have been demonstrated to affect the development and function of immune cells. From the proliferation and differentiation of pluripotent ste...
Gene expression levels were assessed in three biological samples and normalized to GAPDH expression using the Ct method (ΔCt). The following primers were used: GAPDH_Fw: TCCTCTGACTTCAACAGCGA; GAPDH_Rv: GGGTCTTACTCCTTGGAGGC; ROBO1_Fw: GGGGGAGAGAGAGTGGAGAC; ROBO1_Rv: AGGCTCTCCTACTGCAACCA...
We have used a combination of gene expression microarrays and array comparative genomic hybridization (aCGH) to show that meningiomas of all three grades fall into two main molecular groups designated 'low-proliferative' and 'high-proliferative' meningiomas. While all benign meningiomas fall into the ...
Programming gene expression with combinatorial promoters Promoters control the expression of genes in response to one or more transcription factors (TFs). The architecture of a promoter is the arrangement and typ... RS Cox,MG Surette,MB Elowitz - 《Molecular Systems Biology》 被引量: 513发表: ...
The obtained PCR products were inserted into the HindIII and BamHI sites of the pCMV-Flag and pEGFP-N1 vector, respectively, for expression in mammalian cells. All of the constructs described above were sequenced by Hangzhou Tsingke Biology Co. to verify sequences and orientations. 2.3. Cell ...
Transcriptome analysis was performed to elucidate the alterations in gene expression profiles caused by freeze-thawing. The top 20 GO terms among 342 genes of MSCs and 542 genes of HUVECs were determined after freeze-thawing (Additional file 1: Fig. S1A). We found that 97 genes were commonly...
The Radiosensitivity Index Gene Signature Identifies Distinct Tumor Immune Microenvironment Characteristics Associated With Susceptibility to Radiation Therapy 2022, International Journal of Radiation Oncology Biology Physics Citation Excerpt : These types of analyses (eg, IFN-α vs immune cell type vs RSI) ...