Embryonic stem (ES) cells, originally derived from the inner cell mass of blastocysts, have the essential characteristics of pluripotency and self-renewal. Recently, it has been proposed that mouse and human conventional ES cells are present in different developmental stages, namely pre-implantation ...
Secondly, to analyze the AFS cell microenvironment, we injected murine YFPembryonic stem cells (ESC) into the amniotic fluid of E13.5 wild type embryos. Four days after transplantation we found that YFPsorted cells maintained the expression of pluripotency markers and that ESC adherent to the ...
and now begin to concentrate on the function part. While genes and proteins can be manipulated ad nauseum and shown to have various effects on the morphology of neurons, we still lack a good understanding of what taking on one of those few basic cell plans, ...
Embryonic stem (ES) cells, originally derived from the inner cell mass of blastocysts, have the essential characteristics of pluripotency and self-renewal. Recently, it has been proposed that mouse and human conventional ES cells are present in different developmental stages, namely pre-implantation ...
Cell 153, 1327–1339 (2013). Article CAS PubMed PubMed Central Google Scholar Kubo, N., Hu, R., Ye, Z. & Ren, B. MLL3/MLL4 histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation. Preprint at bioRxiv https://doi.org/...
Many othercellsthroughout the body are able to divide into two different types, especially during embryonic development. Yamashita's next steps are to explore whether the nonrandomchromosome segregationseen inDrosophilais a widespread phenomenon that is shared by mammals, including humans. ...
Ever since the first spontaneous germ-cell differentiation studies, using human embryonic stem cells, various strategies, including specific co-cultures, gene over-expression, and addition of growth factors, have been applied for human germ-cell derivation. In line with the variety of differentiation ...
Knockdown of RYBP in embryonic stem cells compromised their ability to form embryoid bodies, likely because of defects in cell proliferation and maintenance of H2AK119ub1 levels. Highlights ► All PRC1 complexes are divided into six groups characterized by six PCGF subunits ► These six groups...
(SPRET/EiJ). This collection comprises a large and diverse array of laboratory strains, including those closely related to commonly used mouse cell lines (BALB/3T3 and L929, derived from BALB/c and C3H related strains, respectively), embryonic stem cell-derived gene knockouts (historically 129 ...
iPSCs—adult cellsthat have been genetically reprogrammed to function likeembryonic stem cells—provide a valuable tool for studying diseases and developing customized drug therapies. Researchers from Columbia University Medical Center used iPSCs differentiated into cardiomyocytes (iPSCs-CMs) to study the ...