Cell 153, 1327–1339 (2013). Article CAS PubMed PubMed Central Google Scholar Kubo, N., Hu, R., Ye, Z. & Ren, B. MLL3/MLL4 histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation. Preprint at bioRxiv https://doi.org/...
Embryonic stem (ES) cells, originally derived from the inner cell mass of blastocysts, have the essential characteristics of pluripotency and self-renewal. Recently, it has been proposed that mouse and human conventional ES cells are present in different developmental stages, namely pre-implantation ...
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature. 2008;455(7216):1124. 70. Didiano D, Hobert O. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Nat Struct Mol Biol. 2006;13(9):849. 71. Seok H...
Ependymal cells are derived from radial glia17, the embryonic neural stem cells18. Recently, these stem cells were shown to have remarkable heterogeneity19, with regionally restricted potential to produce various neuronal subtypes. As descendants of radial glia, ependymal cells may inherit this ...
Embryonic stem (ES) cells, originally derived from the inner cell mass of blastocysts, have the essential characteristics of pluripotency and self-renewal. Recently, it has been proposed that mouse and human conventional ES cells are present in different developmental stages, namely pre-implantation ...
Understanding how distinct cell types arise from multipotent progenitor cells is a major quest in stem cell biology. The liver and pancreas share many aspects of their early development and possibly originate from a common progenitor. However, how liver and pancreas cells diverge from a common endod...
Development of ependymal and postnatal neural stem cells and their origin from a common embryonic progenitor Cell Rep, 27 (2019) 429–441.e3 Google Scholar Regev et al., 2017 A. Regev, S.A. Teichmann, E.S. Lander, I. Amit, C. Benoist, E. Birney, B. Bodenmiller, P. Campbell, P....
Single-cell gene expression analysis in cell subsets defined by surface antigen expression revealed that human embryonic stem cell cultures exist as a continuum of cell states, even under defined conditions that drive self-renewal. The majority of the population expressed canonical pluripotency ...
released “scEnhancer”, an EnhancerAtlas-like database based on single-cell ATAC-seq data drawn from different embryonic time points [22]. Unlike the results using EnhancerAtlas, the majority of scEnhancer datasets had a significant degree of overlap with their REDfly set (45/56, 80%; Fig. ...
R. et al. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res 4(2), 107–16 (2010). 22. Parkinson, J. et al. Translational pharmacokinetic-pharmacodynamic modeling of QTc effects in dog and human. J Pharmacol Toxicol Methods 68(3),...